传统的 NTM 病原学检测方法主要包括抗酸染色及分离培养等,然而由于不少 NTM 生长较为缓慢,导致 TAT 漫长,阳性率较低,而 Q-PCR、mNGS 等新兴的分子生物学手段则很好地弥补了上述缺陷;但同时我们也应注意到,由于 NTM 广泛存在于自然界,因此分子生物学检测结果需要进行慎重的解读、评估及验证。 监制:gyouza 题图来源:参考资料 1参考资料:[1]Lu D, Zhang CH, Chen LJ, et al. Case report of the first cured patient with Mycobacterium Chimaera infection following cardiac valve replacement in the mainland of China. Antimicrob Resist Infect Control. 2021;10(1):141. doi: 10.1186/s13756-021-01003-9 [2]Achermann Y, Rössle M, Hoffmann M, et al. Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera. J Clin Microbiol. 2013;51(6):1769-73. doi: 10.1128/JCM.00435-13[3]Landymore RW, Murphy DA, Marrie TJ, et al. Mycobacterium avium-intracellulare endocarditis causing rupture: replacement and repair with aortic homograft. Can J Cardiol. 1992;8(7):729-32. [4]Hedderwick SA, Bonilla HF, Barg NL, et al. Mycobacterium avium complex endocarditis: spurious diagnosis resulting from laboratory cross contamination. Diagn Microbiol Infect Dis. 1997;27(4):147-50. doi: 10.1016/s0732-8893(97)00030-8[5]Giladi M, Szold O, Elami A, et al. Microbiological cultures of heart valves and valve tags are not valuable for patients without infective endocarditis who are undergoing valve replacement. Clin Infect Dis. 1997;24(5):884-8. doi: 10.1093/clinids/24.5.884[6]Bills ND, Hinrichs SH, Aden TA, et al. Molecular identification of Mycobacterium chimaera as a cause of infection in a patient with chronic obstructive pulmonary disease. Diagn Microbiol Infect Dis. 2009;63(3):292-5. doi: 10.1016/j.diagmicrobio.2008.12.002[7]Hasse B, Hannan MM, Keller PM, et al. International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass. J Hosp Infect. 2020;104(2):214-235. doi: 10.1016/j.jhin.2019.10.009[8]Riccardi N, Monticelli J, Antonello RM, et al. Mycobacterium chimaera infections: An update. J Infect Chemother. 2020;26(3):199-205. doi: 10.1016/j.jiac.2019.11.004[9]Perkins KM, Lawsin A, Hasan NA, et al. Notes from the Field: Mycobacterium chimaera Contamination of Heater-Cooler Devices Used in Cardiac Surgery - United States. MMWR Morb Mortal Wkly Rep. 2016;65(40):1117-1118. doi: 10.15585/mmwr.mm6540a6[10]Sax H, Bloemberg G, Hasse B, et al. Prolonged Outbreak of Mycobacterium chimaera Infection After Open-Chest Heart Surgery. Clin Infect Dis. 2015;61(1):67-75. doi: 10.1093/cid/civ198[11]Scriven JE, Scobie A, Verlan-der NQ, et al. Mycobacterium chimaera infection following cardiac surgery in the United Kingdom Clinical features and outcome of the first 30 cases. Clin Microbiol Infect. 2018;24:1164–70. doi:10.1016/j.cmi.2018.04.027[12]Centers for Disease Control and Prevention. CDC advises hospitals to alert patients at risk from contaminated heater–cooler devices used during cardiac surgery[2016-10-13]. https://emergency.cdc.gov/han/han00397.asp[13]U.S. Food and Drug Administration. FDA Warning Letter to LivaNova (formerly Sorin Group S.p.A.) [2015-12-29].[14]U.S. Food and Drug Administration. FDA Stakeholder call with health care providers and staff of health care facilities and health departments [2016-01-11]. https://www.fda.gov/media/101026/download[15]Baker AW, Maziarz EK, Lewis SS, et al. Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes. Clin Infect Dis. 2021;72(7):1232-1240. doi: 10.1093/cid/ciaa215[16]U.S. Food and Drug Administration. Potential Risk of Infection during Cardiac Surgery When Using the CardioQuip Modular Cooler-Heater Device – Letter to Health Care Providers [2020-09-30]. https://www.fda.gov/medical-devices/letters-health-care-providers/potential-risk-infection-during-cardiac-surgery-when-using-cardioquip-modular-cooler-heater-device[17]国家药品不良反应监测中心, 国家食品药品监督管理总局药品评价中心. 医疗器械警戒快讯 2015年第9期(总第120期)[2015-12-22]. https://www.cdr-adr.org.cn/ylqx_1/Medical_aqjs/Medical_aqjs_jjkx/201512/t20151222_46534.html[18]国家药品不良反应监测中心, 国家食品药品监督管理总局药品评价中心. 医疗器械警戒快讯 2016年第3期(总第123期)[2016-08-12] https://www.cdr-adr.org.cn/ylqx_1/Medical_aqjs/Medical_aqjs_jjkx/201608/t20160812_46559.html[19]上海市药品监督管理局. 索林医疗(上海)有限公司对热交换水箱系统主动召回[2017-03-17]. http://yjj.sh.gov.cn/ylqxzdzh/20191212/0003-33863.html[20]上海市药品监督管理局. 索林医疗(上海)有限公司对热交换水箱系统主动召回[2017-06-19]. http://yjj.sh.gov.cn/ylqxzdzh/20191212/0003-33927.html[21]国家药品监督管理局. 迈柯唯(上海)医疗设备有限公司对医用物理升温仪和人工心肺机-热交换水箱主动召回[2016-09-30]. https://www.nmpa.gov.cn/xxgk/chpzhh/ylqxzhh/ylqxzhhzj/20160930120001220.html[22]国家药品监督管理局. Terumo Cardiovascular Systems Corporation 对人工心肺机-热交换水箱主动召回[2019-01-24]. https://www.nmpa.gov.cn/directory/web/nmpa/xxgk/chpzhh/ylqxzhh/ylqxzhhdf/20190124000001249.html丁香园招聘 1. 新媒体运营实习生(丁香园)协助运营丁香园公众号工作地点:杭州 点此直接投递简历 2. 新媒体运营实习生(丁香早读)独立运营丁香早读栏目工作地点:杭州 点此直接投递简历 3. 新媒体运营(丁香园)独立完成原创内容策划协助运营丁香园公众号 微博等工作地点:杭州点此直接投递简历 也可将简历投至邮箱hujiafeng@dxy.cn邮件标题:投递岗位名称-姓名
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