[前沿]中科院在脑胶质瘤光声分子成像探针领域取得进展
神外前沿讯，近日，中国科学院深圳先进技术研究院分子影像研究团队在脑胶质瘤光声分子成像探针领域取得新进展。相关论文Single-Layer MoS2Nanosheets with Amplified Photoacoustic Effect for Highly Sensitive Photoacoustic Imaging of Orthotopic Brain Tumors 在线发表在国际期刊《先进功能材料》（Advanced Functional Materials）上。
脑胶质瘤是一种严重危害人类中枢神经系统健康的重大脑疾病，它的精准诊疗已成为我国重大且紧迫的健康需求。针对脑胶质瘤边界这一关键科学问题，研究团队制备了强近红外吸收、高弹性、高灵敏的单层二硫化钼纳米探针，结合光声成像技术，实现了小鼠皮下、原位脑胶质瘤的光声分子成像，脑胶质瘤影像边界的高清晰显影，这有望为影像引导脑胶质瘤精准手术提供新的思路和工具。
该研究成果由郑海荣、宋亮和盛宗海团队共同合作完成。围绕脑胶质瘤的精准诊疗，该团队在成像仪器、成像探针和临床转化等方面开展了一系列研究工作，并获国家“973”计划、国家自然科学基金等项目资助。
论文链接：http://onlinelibrary.wiley.com/doi/10.1002/adfm.201603758/full
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摘要：
Photoacoustic (PA) imaging, as a fast growing technology that combines the high contrast of light and large penetration depth of ultrasound, has demonstrated great potential for molecular imaging of cancer. However, PA molecular imaging of orthotopic brain tumors is still challenging, partially due to the limited options and insufficient sensitivity of available PA molecular probes. Here, the direct formation of single-layer (S-MoS2), few-layer (F-MoS2), and multi-layer (M-MoS2) nanosheets by the albumin-assisted exfoliation without further surface modifications is reported. It is demonstrated that the PA effect of the MoS2 nanosheets is highly dependent on their layered nanostructures. Decreasing the number of nanosheet layers from M-MoS2 to S-MoS2 can both significantly enhance the near-infrared light absorption and improve the elastic properties of the nanomaterial, resulting in greatly amplified PA effect. The in vitro experiments demonstrate that the prepared S-MoS2 with excellent biocompatibility can be efficiently internalized into U87 glioma cells, producing strong PA signals for highly sensitive detection of brain tumor cells, with a detection limit of ≈100 cells. Intravenous administration of S-MoS2 to both U87 subcutaneous and orthotopic tumor-bearing mice shows highly efficient tumor retention and significantly enhanced PA contrast. Tumor tissue ≈1.5 mm below the skull can still be clearly visualized in vivo. Previous studies suggest that the fabricated S-MoS2 with amplified PA effect have high potential to serve as an efficient nanoplatform for sensitive PA molecular imaging and hold promising prospect for translational medicine.
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