2020年1月22日，Netflix上线了一部六集纪录片《流行病：如何防止疫情爆发》（Pandemic: How to Prevent an Outbreak）。
该片提出的问题是：下一场大型流行病会在何时爆发？我们又该如何预防和应对？
全剧主要从医护人员和研究者、疫苗开发者的角度出发，将美国、印度、越南和我国等多地面对埃博拉、禽流感、非典、猪流感、冠状病毒等流行疫情的不同情况和启示呈现出来。
第一集：甩不掉的威胁 It Hunts Us
第二集：当务之急 Pandemic is Now
第三集：以攻为守 Seek, Don't Hide
第四集：扎根社区 Hold On to Your Roots
第五集：信仰之力 Prayers Might Work
第六集：永不止步 Don't Stop Now
希望观看全6集的同学，可在公众号后台回复“流行病”获取链接，现在放上第一集的视频及前半部分的双语字幕共大家学习
To walk, I think we'll go on low setting.We may end up surveying both, but...This site is a forgotten place.But it should be a warning to us all.We'll identify the anomalies and mark those out.So you're trying to narrow the focus of the radar pulse, is that it?Yeah, we're looking for a change in the density of the soil.There are some anomalies sort ofpopping up.This is a pretty strong one here, there's one there.At one meter in and then over at three.Each stake represents aprobable body.This is essentially a mass grave.A hundred years ago, a deadly influenza virusinfected hundreds of millions of people around the world.It overwhelmed hospitals.It overwhelmed mortuaries.So towns all over the world needed a quick solution.We could be standing in any number of townsacross the US, or Kenya, India, Vietnam.This grave site is a reminder of the devastationa flu pandemic can wreak.This kind of carnage is not relegated to history.When we talk about another flupandemic happening,it's not a matter of if, but when.-带上听诊器 还有… -嗯 确保防护服都盖住了-Take the stethoscope, and... - Yes, ensure that the gown covers.We have received reports of an outbreak of respiratory illness.Make sure you have a good seal.Give me a thumbs up once you know you have a good seal.About eight other countries around the worldare also reporting similar outbreaks.Unofficial case count is about over 220 with eight deaths.We don't know what the case definition looks likeand we don't know the laboratory analysis of this particular outbreak.We know that we are dealing with something novel,we just don't know exactly what we're dealing with,but some of the patients are not testing positivefor these normal seasonal fluviruses.Currently, the Emergency Department at Kings County Hospitaland so we have set up a mobile satellite emergency department.I'm not doing well. I can't breathe. - Okay. Okay.
I need intubation equipment. There's no intubation equipment.Somebody get the ice. Ashley.I wouldn't turn it off at this point, I don't think we have time.Can you check the X-ray on bed one?Let's go back to the debriefing room.So all who participated, please come to make a circle.I think one of the things that we tried to bake into the simulationwas just healthcare worker safety.I think that was one of the biggest take aways in the previous outbreaks.If I have to take the time out to switch my gownand someone needs to be intubated,I'm gonna pick their life over switching out my garment.We're talking about a severe respiratory disease.Really big lesson learned, and we mentioned this over and over,is that healthcare workers were disproportionally affectedand it shows us where we need to improve on.So if you're not protected, if you can't protect yourself,then how are you gonna help others?My job is to contain the virus here in New York City.What worries me is that it just takes one person to start an outbreak.We're basically human incubators,we can host a number of different diseases.It's just a matter of time where the next pandemic is going to start,we just don'tknow where or how, but we know it will.我记得很小的时候 看过一部叫做"极度恐慌"的电影I remember, at a very young age, watching a movie called Outbreak,and in this movie you hada novel virusthat started in California that quickly spread.Healthcare workers get suited up, and I was like, "Oh, my God,working in that high-risk environment, this is amazing."That was a formative moment forme, and I have been pursuing a careerin infectious disease preparedness ever since.In even a small outbreak, you have what we call "hoarding."We saw this in the H1N1 outbreakwhere vaccines were not madeavailable in the United Statesin a timely fashion because countries were hoarding it...You know, these infectious disease outbreaksare scarier and more deadly than conventional warfare.So this is something that people should pay attention to,but they forget in their day-to-day lives.My job is to remind them.Okay, I'll be there in asecond. Okay.Yeah, I can hear it, too.I wake up in this building. I eatin this building.I put my pajamas on in this building and I sleep in this building.How did I know you'd be the one to make my night?When I came out of medical school...in the back of my mind I still had that visionof what it was to be as mall-town doctor.Very old-school, the one doctor in town.I want you to hold your breath.Big deep breath in and hold it.They saw patients in the clinic,they were the ones that were rotating through the ER.They were the ones seeing the patients in the hospitalwho took care of the patient when they were welland took care of the patient when they were sick.Stickit out and say, "Ah."And took care of the patient when they were hurtand ran into the patientin different social situationsoutside of the hospital or clinic.I need to see what's under there. - Yeah.I had other physicians that talked to meand I'd say, "What advice do you have for me?"And they'd say, "Reconsider."But nobody could dissuade me. I was gonna do it regardless.So were you diagnosed with the flu? - Yeah.Do you remember if it was the A or the B? - I think it was the A.A, okay. - They did both of our noses.That was Wednesday. - You should be at the end of it,but you're not feeling better...Yesterday, my symptoms started getting worse.Okay. Have you been feeling sweats, chills?Chills. He wakes up in a sweat.She said that you have notbeen feeling well at all.That you really haven't been getting over the flu like you ought to.Big deep breath in. Well done. Good. Do that again.I don't have every resource that a large hospital has.I honestly have no idea what I would do in a situation like a pandemic.We're gonna be lower on the totempolein terms of getting replenishment of our resources.Places that have higher populationsare gonna be the places that get that life saving medication first.I think that we would be overwhelmed.We wouldn't be able to manageshould a flu pandemic occur in our little county.We have to follow the virus. Where is the virus located?And the virus is located in birds.My job takes me all over the world.
My main responsibility is trying to prevent, trying to detect,and respond, and control emerging viral threats.There is no single, more dangerous influenza viruscirculating in this planet today than the avian flu in China right now.60% of the people who are infected die.Chinese and global health authoritiesare watching anew strain of bird flu. It's called H7N9.This is definitely one of the most lethal influenza virusesthat we have seen so far.are at pains to say they're on top of this potential outbreak.At least 108 cases, 22 of those people infected died.The recent H7N9 virus has a very high mortality rate.That said, it remains an inefficient virus for infecting people.So far, this virus has not yet spread beyond China,but it could happen at any time.When were these birds last vaccinated? - Seven days ago.So they had a problem with neighboring farms having outbreaks?Some people bought sick chickens at the market.There are almost endless variations of the influenza virus.They're denoted by different combinations of H's and N's, such as H5N1.The H's and N's ultimately definethe physical characteristics an influenza virus will haveand just how deadly that infection might be.The pandemic flus and these asonal flus are profoundly different.A pandemic influenza will likely come from an animaland it will be a new and novel, never-seen-before virus.When a novel virus emerges from animals, we will not have natural immunity.Our systems will have no means to fight the infection off,which means it has the potential for being very deadly.That's why there are researchers around the world、committed to developing auniversal vaccinethat will be effective against any and all influenza viruses.I don't really get stage fright anymore.I used to do this thing where if I knew I was about to go on the stage,my heart would start beating and I'd feel like I was gonna pass out,but I knew for the work that I wanted to do,I had to be an effective communicator.If I wasn't able to communicate my science,then it was almost like the science didn't exist.Can you get the slides up?That's a different slide there.All right, good afternoon, NewYork.So, yeah, I'm the co-founder, Chief Science Officer,and the Chairman of Distributed Bio,and this afternoon I'm gonna share with youthe story of a slow-burning revolution in biologic the rapeutic discovery.I never memorize a specific speech.I think about the arc of the story I'm gonna tell,and really good story telling,those rules apply to science.It's basically the same rulesthat our ancestors did around the camp fire, right?First you have to introduce the terrible monster.In this case, it's influenza.
The problem is that the virus mutates so quicklythat your immune response becomes obsolete by the next year.We have created these amazing vaccine technologies可以被认为是自从卫生设备与火以来 最伟大的发明that are arguably the greatest advances since sanitation and fire,and yet they don't work on rapidly mutating viruses,like the flu, for instance.And for a while we thought we were just stuck with this.They're never really gonna be able to solve the problemof having a good single shotthat's gonna solve our risk of being exposed to flu.Then you present the hero.That there's some new technology that exists,that could potentially create a break through.We're making avaccine that could treat all future versions of flu.So, fundamentally, our approach was different,because we tested against future and past strains.Under some circumstances,some people end up producing these nice antibodiesthat hit all the strains or many of the strains of flu,and they enjoy broad protection.You all might have those friends, right?It's that annoying hippie friend of yours who's like,I never take the flu shot and I'm fine."Right?Some of them may be right.But why the hell aren't we all protected all the time?Our approach was able to neutralize virusesas well as protect against future viral variants.I met Jake Glanville in the fall of 2014.He knew that I had skills that he would needif he wanted to launch this vaccine program.Okay, so I can add the antibody to this one, then?Jake just thinks outside the box.He thinks of these crazy ideas that are completely out of the norm.Okay, the NHS and EHC are added, so clock's ticking now.我们已经完成了多次动物研究 我们知道这是可重现的We've done multiple animal studies so we know that this is reproducible.What we're seeing is real.I want to prove that my research and Jake's researchThis vaccine could eradicate influenza as we know it.This will not work at all.Sir, this one is expected H1N1.There has been an alarming rise in the swine fluor H1N1 cases in India this year.The situation is turning rather serious with the fatalities increasing by the day.印度北部的拉贾斯坦邦 遭遇了最严重的H1N1病毒袭击The North Indian State of Rajasthan has been worst hit by the H1N1 virus.Negative. It's negative. - But, look.The shadow is still here.And there are some light ones here.Let us see how you feel without oxygen.Should we continue with Tamiflu?It's day six today, right? Give it for one more day.Tamiflu, stop after seven days.We will stop it tomorrow.Swine flu is a very rapidly progressing disease. Very rapidly.In just a few days, it can affect both of the lungs,and it is a life-threatening disease.All patients came with throat pain, sneezing, fever, body ache.But a patient who has nausea, vomiting, along with breathlessness,"and he says "trouble some cough,""always think "swine flu."If it's not diagnosed properly at an early stage,it is difficult to treat.The problem is, when she came here,she had 60%-70% saturation.If she had been on the road, she would've died.We will shift to the ICU. Then treatment will start.The later they come, the more laborious it gets to breathe,and it becomes a matter of life or death.Biggest challenge with fluis not being lulled into acceptance of seasonal fluas all we have to worry about.Because every once in a while, there is a variant of flu that emergesthat poses an existential threat to us as a species.