09.20 线上活动 | 宾大牙医学院新研究：嚼口香糖也能防新冠？

09月

20

星期二  北京时间  20:00

September 20th, 8:00 AM Eastern time  

Chewing gums trap COVID-19 and Flu viruses – Clinical trial launched at Penn

宾大牙医学院新研究：嚼口香糖也能防新冠？

语言：英语                       线上活动

活动介绍

THE EVENT

宾夕法尼亚大学牙医学院对新冠防治的研究别具一格。牙医学院基本和转化科学副主席、美国科学推进协会研究员、意大利国家科学院第14名美国院士 Henry Daniell 教授，将和大家在线分享他的科研团队对防新冠口香糖的研究。

研究表明，口腔唾液腺为病毒复制的重要场所，病毒的口腔传播比鼻腔传播要高。咀嚼具有病毒控制蛋白的口香糖对于抑制病毒复制传播有效果。目前宾大医院、宾大牙医学院正在对相关研究进行临床试验。

Current vaccines protect vaccinated individuals from severity of COVID-19.  However, repetitive vaccinations and boosters do not prevent transmission of SARS-CoV-2.  It is known that fully vaccinated individuals with breakthrough infections have peak viral loads similar to unvaccinated and transmit SARS-CoV-2 in household settings, with or without symptoms.  

In order to address this problem, our lab has developed viral trap proteins that bind directly to the viral surface.  When COVID-19 patient saliva is mixed with the chewing gum containing viral trap protein, virus is trapped in the gum and the trap protein closes their gates of entry into human cells.  Furthermore, swallowing saliva with the virus trap protein kills virus lodged in their throat, the primary site of infection.  This approach not only works for COVID-19 but we have shown it is efficient in neutralizing virulent influenza (Flu) viruses and could be applied to several other viruses.

Because salivary glands in the mouth are primary sites of virus replication, oral transmission is 3-5 orders of magnitude higher than nasal transmission. Speaking four words transmits more virus than one hour of maskless breathing.  Therefore, chewing virus trap gum should help in minimizing transmission, in addition to neutralizing self-infection. Similar to vaccinations inducing immunity, decreasing viral load using chewing gum could also help develop natural immunity by providing limited viral challenge. 

FDA has approved chewing gum containing virus trap protein for testing and clinical trials are launched at Penn hospitals to evaluate viral loads, before and after chewing therapeutic gums.  After evaluation of several thousand saliva samples, we intend to apply for Emergency Use Authorization with FDA.   For more details, please click on the link below. https://penntoday.upenn.edu/news/chewing-curb-covid

讲者介绍

THE SPEAKER

Dr. Henry Daniell

W.D. Miller Professor, Vice Chair, Basic and Translational Sciences at the University of Pennsylvania School of Dental Medicine

Dr. Daniell is the W.D. Miller Professor, Vice Chair, Basic and Translational Sciences at the University of Pennsylvania School of Dental Medicine. He is a Fellow of the American Association for the Advancement of Science (2007) and 14th American member of the National Academy of Sciences, Italy in 240 years (Ben Franklin is the first American member of this oldest national academy). He is the Editor in Chief of the Plant Biotechnology Journal, Oxford, UK and the recipient of several awards including the American Diabetes Association, American Heart Association, Bayer Hemophilia global award and Bill and Melinda Gates Foundation Award for outstanding contributions to lower the cost of biopharmaceuticals. He pioneered chloroplast genetic engineering technology to produce and deliver affordable biopharmaceuticals to treat major metabolic or genetic disorders, including Alzheimer’s, diabetes, hypertension, hemophilia and retinopathy. Booster vaccines are developed in chloroplasts to prevent global infectious diseases like tuberculosis, malaria, cholera, anthrax, plague, polio and more recently COVID-19. Studies with FDA and CDC funded by the Gates Foundation, NIH SMARTT program or major pharmaceutical companies facilitated advancement of these innovations to the clinic.  More recently, viral trap proteins in chewing gum to reduce SARS-CoV-2 infection/transmission is advanced to Phase I/II clinical trial, after receiving FDA approval of IND.  He has published >300 peered reviewed articles (H-index 73, Google Scholar 92) and >100 patents.  Details are available in the Google Scholar link: http://scholar.google.com/citations?user=7sow4jwAAAAJ&hl=en

报名方式

REGISTRATION

活动将通过Zoom平台进行。下载和了解使用方法请访问下列链接：https://zoom.us/download。请点击“阅读原文”注册活动。活动链接将在北京时间9月20日17:00通过邮件形式发送到您预留的邮箱。如果您对此话题感兴趣，请在注册时留下您的问题。讲者将会选取一些问题进行解答。

The webinar will use Zoom as its platform. Click "Read More" to register. The link will be distributed through an email at 5 PM on September 20th (Beijing Time). If you are interested in this topic, please leave your questions while the registration. The speaker will select some questions to answer.

Penn Dental Medicine

Shaping the future of dental education, research, and clinical care.

宾大沃顿中国中心由美国宾夕法尼亚大学和沃顿商学院于2015年3月共同成立，旨在进一步加强宾大与中国的学术和文化交流。宾大沃顿中国中心将为宾大教授、学生、在华校友和各界友人进行知识分享和文化交流提供服务，也将成为连接中国和宾夕法尼亚大学的纽带，促进双方在研究和教学领域的合作。

The March 2015 opening of the Penn Wharton China Center (PWCC) represented a substantial commitment to advance the long history of engagement with China by the Wharton School and its parent university, the University of Pennsylvania (Penn) PWCC provides on-the-ground support for the growing numbers of programs and collaborations between Penn’s 12 schools and many academic, government, and business partners throughout China. 

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