强生-研发职位：Associate Director, Medicinal Chemistry
Medicinal Chemistry, Associate Director
Location: Shanghai, China
Description:
We are hiring an experienced medicinal Chemist in Shanghai Discovery Center at Johnson & Johnson as an Associate Director.
This position will require the candidate to possess and leverage deep knowledge and capabilities to deliver differentiated clinical candidates to the Janssen product development pipeline. Using a mix of internal and external resources, the senior chemist will partner with key stakeholders in the field of oncology, virology and immunology, represent medicinal chemistry on cross-functional project teams, and be co-responsible for building, managing, and delivering the chemical matter of the clinical pipeline.
As a chemistry leader, drive and direct medicinal chemistry functions for one or more drug discovery projects. The main job functions include:
Working in concert with partners in molecular and cellular biology, pharmacology, molecular informatics, ADME, structural biology, chemical development, and other key functions;
Analyze screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies;
Maybe involved in supervising and/or directing synthetic chemistry activities at contract research organizations (CROs) or internally;
Participate in portfolio and stage-gate reviews, aid in the preparation and presentation of dossiers for clinical candidate nomination and compound advancement;
Participate in shaping and implementing strategies that support Medicinal Chemistry growth objectives;
Serve as a scientific expert in medicinal chemistry and provide recommendations regarding new targets and emerging external opportunities;
Ensure optimal interaction/communication and provide updates on project status to Discovery Research leadership.
Qualifications:
PhD in synthetic or medicinal chemistry is required, preferably with postdoctoral experience;
At least 8+ years of experience in the biotechnology or pharmaceutical industry with a proven track record of innovative projects and key contributions to clinical candidate selection;
Prior project leadership is required;
Broad experience and proven accomplishments in a field of Medicinal Chemistry, preferably in one or more fields of oncology, immunology and virology, with operational skills for managing discovery programs at the level of a team leader and a proven track record of delivering clinical candidates is much desirable;
Candidates will have a track record of successful contributions to, and leadership of, innovative drug discovery projects, exemplified by a record of patent inventorship, conference presentation and peer-reviewed publication;
Expert knowledge of modern methods of synthetic and medicinal chemistry with ability to successfully and simultaneously conduct medicinal chemistry on multiple projects is required;
Solid understanding of cellular /molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and the formulations for the in vivo evaluation of drug candidates is required;
Strong knowledge of computational chemistry methods and working knowledge of biophysical methods such as X-ray crystallography and macromolecular NMR is required;
Experience in leading multi-disciplinary, cross-functional teams to advance projects, with involvement in supporting cross-company/external collaborations or partnerships is preferred;
Ability to integrate multiple R&D disciplines into a successful strategy and project plan is required;
Candidate must have strong problem solving skills for developing creative, innovative solutions and meeting project objectives;
Candidate must have demonstrated influence, negotiation, and conflict resolution skills, including the ability to succeed as a team player;
Experience in chemistry research in China and setting new chemistry labs are valuable;
Strong oral and written communications skills in English;
Fluent in Chinese is a plus but not required.
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