[有偿专区]随机抽样批量做差异分析

求助：

利用TCGA数据库，我筛选了结肠癌差异miRNAs。样本中包含8个健康对照和272个癌症样本。目前审稿人质疑8个健康样本过少，会导致结果不稳定。

要求如下：

The best and easiest way to do this is to use a bootstrap technique, to sample with replacement samples for healthy patients and check how stable results are based on the new samples. It shall be enough to check how large is the overlap between biomarkers identified on original data and biomarkers identified on bootstrap sample. 

希望有人能帮我解决这一问题，报酬详谈，谢谢！

感兴趣的朋友可以后台回复，谢谢~~~

需要会R语言，懂差异分析，随机抽样，需要一些统计学功底，不要乱来。