学术报告预告‖Brian MacVicar院士、Terrance P. Snutch院士、Yutian Wang院士深圳开讲
BCBDI
中国科学院深圳先进技术研究院－MIT麦戈文联合脑认知与脑疾病研究所
The Brain Cognition & Brain Disease Institute for Collaboration Research of SIAT at CAS and the McGovern Institute at MIT
报告1
主题：New Roles for Pericytes and Astrocytes in the Function, Repair and Regeneration of Cerebral Blood Vessels after Stroke
时间：2018年09月30日 14:00
地点：A504 会议室
主持：王立平 研究员
嘉宾：Brian MacVicar, PhD
Co-Director | Djavad Mowafaghian Centre for Brain Health
Canada Research Chair in Neuroscience
Dept. of Psychiatry | Faculty of Medicine | University of British Columbia
报告简介：
Brain pericytes of the neurovascular unit (NVU) are critical for the developmental maturation of cerebral blood vessels and for the integrity of the blood-brain barrier (BBB). Pericytes are perivascular mural cells that share similarities with mesenchymal progenitors (MP), a cellular pool critical in supporting peripheral tissue regeneration. Therefore we examined what role brain pericytes play in repairing and restoring the cerebral microvasculature following stroke using a new transgenic MP reporter mouse that specifically identifies brain pericytes. Here we show that after stroke, pericytes enter the cell cycle to support cerebrovascular regeneration in a manner similar to their role during development. Following stroke, pericytes proliferate and migrate into the infarct region where they accumulate inside a border of reactive astrocytes. The pericyte-astrocyte interface forms an angiogenic zone that progressively migrates into the ischemic core, thereby supporting a wave of tissue revascularization. Within a few weeks normal vessels with an intact BBB are found perfusing the previously ischemic cortical area.
报告2
主题：An Unexpected Link Between Congenital Migraine and Sudden Unexpected Death in Epilepsy
时间：2018年09月30日 15:00
地点：A504 会议室
主持：王立平 研究员
嘉宾：Terrance P. Snutch, PhD
Professor and Canada Research Chair in Neurobiology
and Biotechnology-Genomics, Michael Smith Laboratories
& Director of Translational Neuroscience, Djavad Mowafaghian Centre for Brain Health University of British Columbia
报告简介：
Sudden Unexpected Death in Epilepsy (SUDEP) is strongly linked to seizure activity yet ~30% of people with epilepsy do not adequately respond to current treatments and little is known concerning the underlying mechanism of SUDEP. We have discovered that a mouse model of Familial Hemiplegic Migraine Type-1 (P/Q-type calcium channel defect) is associated with sudden death. Combining DW-MRI to examine spreading depolarization (SD) with high spatiotemporal visualization and EEG recording to correlate with seizure activity, we identify subcortical regions susceptible to seizures and concomitant SD that together result in SUDEP. Further optogenetic and biophysical experiments confirm that selected subcortical regions are sensitive to SD and propagation to the brainstem likely due to an underlying enhanced neuronal excitability.
报告3
主题：Development of NMDAR Positive Allosteric Modulators as Novel Therapeutics for Brain Disorders
时间：2018年09月30日 16:00
地点：A504 会议室
主持：王立平 研究员
嘉宾：Yutian Wang , PhD
Professor of Djavad Mowafaghian Centre for Brain Health
and Department of Medicine/Neurology,
University of British Columbia, Vancouver, Canada
报告简介：
The N-methyl-D-aspartate subtype of glutamate receptor (NMDAR) is fundamental to many normal brain functions such as neurodevelopment, cognition and memory. As such, its dysfunction contributes to the pathogenesis of many brain disorders/diseases ranging from acute and chronic neurodegeneration to mental illnesses. Native NMDARs are tetrameric complexes comprised of GNR1 subunits with at least one type of GluN2 subunit. Depending on the GluN2 subunits, NMDARs may have distinct functions. Synaptic, predominantly GluN2A-containing, receptors are thought to be responsible for promoting the induction of long-term potentiation and neuronal survival. In contrast, extra-synaptic, predominantly GluN2B-containing, receptors appear to promote the induction of long-term depression and neuronal death. Using computer-based receptor modeling, chemical library screening, and functional characterizations, we have recently developed a class of GluN2A-NMDAR positive allosteric potentiators (Npams) and demonstrated their roles in activating pro-survival signaling and reducing excitotoxic/ischemic neuronal injuries in vitro and in vivo. Our results not only validate GluN2A-specific roles of NMDARs in promoting cell survival, but also lead to the development of a new class of NMDAR-based neuroprotective modulators in stroke.
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编辑：小伶俐
脑科学与脑技术
中科院深圳先进技术研究院
MIT麦戈文联合
脑认知与脑疾病研究所
严谨治学
创新驱动