结构速递 | 一周“结构”要览 VOL.59(4.17~4.23)
上周发布了哪些“结构”文章？又取得了哪些科研进展？
结构速递栏目以每周“结构”相关领域刊文为主题，梳理一周结构发文大事记，“结构速递”为您传递最新、最快、最权威的结构资讯。
2023.4.17~2023.4.23
CNS刊登文章
01
Nature
2023/4/19
“Lesion recognition by XPC, TFIIH and XPA in DNA excision repair”
核苷酸切除修复（Nucleotide Excision Repair）可以去除由紫外线、顺铂样化合物和大量加合物引起的DNA损伤。在全基因组修复中被XPC初步识别或在转录偶联修复中被暂停的RNA聚合酶识别后，受损的DNA被转移到7个亚基的TFIIH核心复合体(Core7)中进行验证，并被XPF和XPG核酸酶双重切割。在转录起始或DNA修复中，酵母XPC同源物Rad4和TFIIH在转录起始或DNA修复中的作用已分别被报道。两种不同的病变识别通路如何相互关联，以及Core7的XPB和XPD解旋酶是如何移动DNA损伤尚不清楚。
来自美国国立卫生研究院的Wei Yang和日本神户大学的Kaoru Sugasawa合作解析了人类XPC识别DNA损伤的冷冻电镜结构，展示了XPC如何将DNA损伤传递给Core7和XPA蛋白质。XPA蛋白质位于XPB和XPD之间，可以弯曲DNA双链并移动XPC和DNA损伤，从而让DNA损伤位点位于Core7之外，与RNA聚合酶发生的情况相似。综上，本研究揭示了核苷酸切除修复过程中多个蛋白质的相互作用和复杂的步骤，有助于我们理解DNA修复机制的分子细节。
原文链接
https://www.nature.com/articles/s41586-023-05959-z
Science
本周无
Cell
本周无
2023.4.17~2023.4.23
子刊刊登文章
01
Molecular Cell
4.21
“The mechanism of STING autoinhibition and activation”
02
Nature Structural & Molecular Biology
4.17
1.“Structures of human primosome elongation complexes”
4.20
2.“Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site”
4.20
3.“Mechanism of RecF–RecO–RecR cooperation in bacterial homologous recombination”
4.20
4.“Structural inventory of cotranslational protein folding by the eukaryotic RAC complex”
4.20
5. “Structure of a SIN3–HDAC complex from budding yeast”
4.20
6. “Structural basis of centromeric cohesion protection”
03
Nature Communications
4.17
1. “Central cavity dehydration as a gating mechanism of potassium channels”
4.17
2. “Structure and mechanism of the alkane-oxidizing enzyme AlkB”
4.17
3.“Hsp90 provides a platform for kinase dephosphorylation by PP5”
4.18
4. “PeSTo: parameter-free geometric deep learning for accurate prediction of protein binding interfaces”
4.19
5.“The structural basis of tRNA recognition by arginyl-tRNA-protein transferase”
4.19
6.“Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b”
4.19
7.“Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase”
4.19
8.“Allosteric role of the citrate synthase homology domain of ATP citrate lyase”
4.20
9.“Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase”
4.20
10.“Structural insights into RNase J that plays an essential role in Mycobacterium tuberculosis RNA metabolism”
4.20
11.“Characterization of a fold in TANGO1 evolved from SH3 domains for the export of bulky cargos”
4.22
12.“DNA-binding mechanism and evolution of replication protein A”
4.22
13.“IS21 family transposase cleaved donor complex traps two right-handed superhelical crossings”
4.22
14.“Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases”
04
Science Advances
4.19
1.“Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant”
4.21
2.“Structural basis for CEP192-mediated regulation of centrosomal AURKA”
Cell Research
本周无
作者 | 谭佳鑫
审稿 | 肖媛
责编 | 囡囡
设计、排版 | 可洲
推荐阅读
点击上方卡片
关注我们吧
END
我知道你“在看”哟