新年伊始，万象更新——第五期《肿瘤标志物通讯》再次出发！
“新年伊始，万象更新”，刚刚过完温馨的新春佳节，《肿瘤标志物通讯》再次出发，迎来了第五期。本期《肿瘤标志物通讯》由王书奎教授担任主编，杜清博士、张岩教授、叶庆教授、张恒辉博士以及李慧教授分别担任基础理论、创新技术、临床应用、产业发展及指南政策五个篇章的执行主编，五位专家经过精心遴选与大家分享了28篇来自Nature及子刊、Cell及子刊、Cancer Discovery、Genome Research、Lancet Oncology、Cancer Cell、JAMA等顶级学术期刊上的最新研究成果，对其中19篇进行点评，并推荐了17篇简讯报道。
本期还特别推出由南方医科大学南方医院申鹏教授分享的“免疫治疗疗效预测生物标志物探索”PPT资料。并发布2019年肿瘤标志专委会全国巡讲培训计划。希望本期《肿瘤标志物通讯》能为大家带来最新、最前沿、最实用的科技信息！
奔跑2019，我们都是追梦人！愿《肿瘤标志物通讯》越办越好！
1. 曹雪涛教授发现乳腺癌患者易发淋巴结转移新机制
Gu Y, Liu Y, Fu L, et al. Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG[J]. Nat Med, 2019, 25(2):312-322.
2. 崔儒涛/邓贤明/王鹏合作组报道首例STK19靶向化合物抑制NRAS介导的黑色素瘤生成
Yin C, Zhu B, Zhang T, et al. Pharmacological targeting of STK19 inhibits oncogenic NRAS driven melanomagenesis[J]. Cell, 2019, 176(5):1113-1127.
3. 一种新型lncRNA带来的抗癌新思考
Luo J, Langer LF, Liu J. A novel role of LncRNA in regulating tumor metabolism in regulating tumor metabolism and angiogenesis under hypoxia[J]. Cancer Commun (Lond), 2019, 4, 39(1):2.
4. 科学家们发现高脂饮食可能加速诱发结直肠癌
Fu T, Coulter S, Yoshihara E, et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation[J]. Cell, 2019, 176(5):1098-1112.
5. 哈佛大牛破解免疫疗法耐药性！ADAR1基因是关键！
Ishizuka JJ, Manguso RT, Cheruiyot CK, et al. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade[J]. Nature, 2019, 565(7737):43-48.
6. 首个全分辨率的人类基因组遗传图谱发布
Halldorsson BV, Palsson G, Stefansson OA, et al. Characterizing mutagenic effects of recombination through a sequence-level genetic map[J]. Science, 2019, 363(6425).
7. 国家纳米中心孙佳姝组开发外泌体检测新方法用于癌症早期诊断
Liu C, Zhao JX, Tian F, et al. Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers[J]. Nat Bio Eng, 2019.
8. 成本仅为WGBS一半！牛津大学成功开发新型DNA甲基化测序方法
Liu Y, Siejka-Zielińska P, Velikova G, et al. Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution[J]. Nat Biotechnol, 2019, 25.
9. 科学家开发出一种能对单一血液样本中成百上千种蛋白质检测的新技术！
Dagher M, Kleinman M, Ng A, et al. Ensemble multicolour FRET model enables barcoding at extreme FRET levels[J]. Nat Nanotechnol, 2018, 13(10):925-932.
10. 科学家开发出可高效识别不同类型癌细胞的人工智能系统
Toratani M, Konno M, Asai A, et al. A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones[J]. Cancer Res, 2018, 78(23):6703-6707.
11. 迄今为止最大规模的TMB预测肿瘤免疫治疗效果研究
Samstein RM, Lee CH, Shoushtari AN, et al. Tumor mutational load predicts survival after immunotherapy across multiple cancer types[J]. Nat Genet, 2019, 51(2):202-206.
12. 警告人类里程碑免疫疗法抗PD1的严重致命并发症，死亡率高达46%
Moslehi JJ, Salem JE, Sosman JA, et al. Increased reporting of fatal immune checkpoint inhibitor-associated myocarditis[J]. 2018, 391(10124):933.
13. 一个新的“免疫检查点”，有望与癌症疫苗联合抗癌
van Montfoort N, Borst L, Korrer MJ, NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines[J]. Cell, 2018, 13;175(7):1744-1755.
14. TMB可预测多种癌症的免疫治疗后的存活率
Samstein RM, Lee CH, Shoushtari AN, et al. Tumor mutational load predicts survival after immunotherapy across multiple cancer types[J]. Nat Genet, 2019, 51(2):202-206.
15. 乳腺癌最难治疗亚型！科学家发明新型智能靶向药物！
Bardia A, Mayer IA, Vahdat LT, et al. Sacituzumab Govitecan-hziy in Refractory Metastatic
Triple-Negative Breast Cancer[J]. N Engl J Med, 2019, 380(8):741-751.
16. 湘雅医学院和贵林医科大学学者共同发现新的肝癌检测血清标志物
Xu Ye, Cunyan, Li Xuyu Zu, et al. A Large-Scale Multicenter Study Validates AKR1B10 as a New Prevalent Serum Marker for Detection of Hepatocellular Carcinoma[J]. Hepatology, 2019:23.
17. 揭示19种癌症类型中肿瘤缺氧的常见标志物
Bhandari V, Hoey C, Liu LY, et al. Molecular landmarks of tumor hypoxia across cancer types[J]. Nature Genetics, 2019, 51(2):308-318.
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