SSB专刊推荐┃Pathway and protein engineering for biosynthesis
合成生物学的飞速发展将有助于建立高效生物合成生物系统，实现化学品或天然产物的绿色可持续生产。然而，构建生物合成路线充满挑战，其需要高效酶、生物合成途径以及便捷的使能技术。蛋白质 (酶) 是生命活动的直接执行者，也是构建高效生物合成途径的重要元素，通过酶的挖掘和蛋白质工程对酶进行系统表征与改造，提高酶催化性能以及关键步骤的合成效率。进一步利用工程化思维将不同酶分子组装为代谢途径与网络，并通过途径工程平衡代谢网络，以提高生物合成效率。此外，便捷的使能技术将有促于酶分子、代谢途径和细胞整体性能优化，从而促进目标产物生物合成效率。
为了更好地探索蛋白质和途径工程，助力生物合成的前沿进展，Synthetic and Systems Biotechnology特别设置“Pathway and Protein Engineering for Biosynthesis”为主题的特刊，由大连化学物理研究所周雍进研究员、德国歌德大学的Martin Grininger教授与德克萨斯大学奥斯汀分校的Hal Alper教授担任特约编辑，邀请多位国内外知名学者分享其科研成果。本次特刊共收录八篇评论文章和九篇原创研究文章，重点介绍和展示了Pathway and Protein Engineering及其在合成生物学应用中的最新进展。
文 章 列 表
#01
Identification of (-)-bornyl diphosphate synthase from Blumea balsamifera and its application for (-)-borneol biosynthesis in Saccharomyces cerevisiae
Guanghong Cui & Luqi Huang, et al.
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 490-497
https://doi.org/10.1016/j.synbio.2021.12.004
#02
Protein-protein interface analysis of the non-ribosomal peptide synthetase peptidyl carrier protein and enzymatic domains
Joshua C. Corpuz, Javier O. Sanlley, Michael D. Burkart
Synth. Syst. Biotechnol., Volume 7, Issue 2, June 2022, Pages 677-688
https://doi.org/10.1016/j.synbio.2022.02.006
#03
Fragment antigen binding domains (Fabs) as tools to study assembly-line polyketide synthases
Katarina M. Guzman, Chaitan Khosla
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 506-512
https://doi.org/10.1016/j.synbio.2021.12.003
#04
Glycosyltransferases: mining, engineering and applications in biosynthesis of glycosylated plant natural products
Guang-Yu Yang et al.
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 602-620
https://doi.org/10.1016/j.synbio.2022.01.001
#05
Current state and future perspectives of cytochrome P450 enzymes for C–H and C=C oxygenation
Wei Song et al.
Synth. Syst. Biotechnol., Volume 7, Issue 3, September 2022, Pages 887-899
https://doi.org/10.1016/j.synbio.2022.04.009
#06
Enhanced production of poly-γ-glutamic acid via optimizing the expression cassette of Vitreoscilla hemoglobin in Bacillus licheniformis
Dong Wang & Shouwen Chen et al.
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 567-573
https://doi.org/10.1016/j.synbio.2022.01.006
#07
One stone two birds: biosynthesis of 3-hydroxypropionic acid from CO2 and syngas-derived acetic acid in Escherichia coli
Hui Wu et al.
Synth. Syst. Biotechnol., Volume 6, Issue 3, September 2021, Pages 144-152
https://doi.org/10.1016/j.synbio.2021.06.003
#08
Reprogramming the metabolism of Synechocystis PCC 6803 by regulating the plastoquinone biosynthesis
Hui Wu et al.
Synth. Syst. Biotechnol., Volume 6, Issue 4, December 2021, Pages 351-359
https://doi.org/10.1016/j.synbio.2021.10.004
#09
Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production
Robert Mans et al.
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 554-566
https://doi.org/10.1016/j.synbio.2021.12.010
#10
Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton
Ran Liu & Tiangang Liu et al.
Synth. Syst. Biotechnol., Volume 6, Issue 4, December 2021, Pages 292-301
https://doi.org/10.1016/j.synbio.2021.09.008
#11
Complex peptide natural products: biosynthetic principles, challenges and opportunities for pathway engineering
Eric J.N. Helfrich et al.
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 631-647
https://doi.org/10.1016/j.synbio.2022.01.007
#12
Strategies to increase tolerance and robustness of industrial microorganisms
Yun Chen et al.
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 533-540
https://doi.org/10.1016/j.synbio.2021.12.009
#13
Research progress of pathway and genome evolution in microbes
Yunzi Luo et al.
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 648-656
https://doi.org/10.1016/j.synbio.2022.01.004
#14
Engineered DNase-inactive Cpf1 variants to improve targeting scope for base editing in E. coli
Chunbo Lou & Bian Wu et al.
Synth. Syst. Biotechnol., Volume 6, Issue 4, December 2021, Pages 326-334
https://doi.org/10.1016/j.synbio.2021.09.002
#15
Characterizing and engineering promoters for metabolic engineering of Ogataea polymorpha
Xiaoyu Guo & Jiaoqi Gao et al.
Synth. Syst. Biotechnol., Volume 7, Issue 1, March 2022, Pages 498-505
https://doi.org/10.1016/j.synbio.2021.12.005
#16
A FAIR-compliant parts catalogue for genome engineering and expression control in Saccharomyces cerevisiae
Michael K. Jensen et al.
Synth. Syst. Biotechnol., Volume 7, Issue 2, June 2022, Pages 657-663
https://doi.org/10.1016/j.synbio.2022.02.001
#17
Comparative proteomics analysis of Pichia pastoris cultivating in glucose and methanol
Yongjin Zhou & Lihua Zhang et al.
Synth. Syst. Biotechnol., Volume 7, Issue 3, September 2022, Pages 862-868
https://doi.org/10.1016/j.synbio.2022.04.005
期 刊 介 绍
Synthetic and Systems Biotechnology 是高质量国际开放获取期刊，创刊于2016年。期刊覆盖合成生物学、系统生物学以及生物医药等领域的各个方面。
Synthetic and Systems Biotechnology 发表的文章和期刊征稿活动将及时在公众号进行分享，欢迎学者们关注话题集#合成和系统生物技术（SSB），及时掌握期刊研究动态。
期刊现已被SCIE、EMBASE、PubMed Central、Scopus、CSCD等重要数据库收录。
2021 Impact Factor: 4.692;
5-Year Impact Factor: 5.23; JCR分区Q2
2021 CiteScore: 6.60, 位列学科Q1区
2021中科院分区2区
入选2019年中国科技期刊卓越行动计划高起点新刊项目
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