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Chemical Science作者聚焦 – 四川大学冯小明院士

2016-12-30 RSC Publishing RSCPublishing RSCPublishing

Professor Xiaoming Feng

Sichuan University, China 

冯小明院士研究团队设计合成了具柔性直链烷基链接的C2对称双氮氧酰胺化合物,建立了结构多样性、可满足不同反应需求的手性双氮氧-金属络合物催化剂库,是目前对反应类型和底物最具广谱性、价格最低的催化剂之一。这是一类具有自主知识产权的新型“优势手性配体”,突破了对配体刚性骨架的传统要求,获得了具有最佳“手性口袋效应”的手性催化剂,为新手性催化剂的设计提供了新思路。此外,运用双功能催化、分子识别、自组装、不对称活化等新策略和新概念,建立了胍-酰胺和二胺类双功能有机催化剂库和组合配体金属络合物催化剂库。利用这些自己发展的上述催化剂,高效高选择性地实现了30多类重要不对称催化反应。该类催化剂还显示了一些独特的催化性能,实现了7类具有挑战性的不对称催化新反应,其中一类反应被Elsevier出版社的有机人名反应专著冠名为“Roskamp–Feng”反应。

Professor Xiaoming Feng was elected as Academician by the Chinese Academy of Sciences in 2013, awarded The 2nd Class of National Natural Science Award in 2012, The 1st Class of Research Achievements in Natural Science of Ministry of Education in 2009, the Special Professor of the Chang Jiang Scholars in 2005 and the National Science Fund for Distinguished Young Scholars in 2002.

• Professor at the College of Chemistry, Sichuan University, China since 2000

• Postdoc with Professor Yian Shi, Colorado State University, Fort Collins (USA) 1998 - 1999 

• PhD in Chemistry, Institute of Chemistry, Chinese Academy of Sciences, China 1993–1996,  under supervision of Professors Zhitang Huang and Yaozhong Jiang

• Bachelor and Master Degree obtained from Lanzhou University in 1985 and in 1988 

Main Research Interests

Enantioselective Catalysis 

New Reaction Methodology 

Organic Synthesis

Published papers in Chemical Science in 2016

A new approach to the asymmetric Mannich reaction catalyzed by chiral N,N′-dioxide–metal complexes

Xiangjin Lian, Lili Lin, Kai Fu, Baiwei Ma, Xiaohua Liu and   Xiaoming Feng*  

Chem. Sci., 2017, Advance Article

DOI: 10.1039/C6SC03902B

A highly efficient asymmetric Mannich-type reaction between α-tetralone-derived β-keto esters/amides and 1,3,5-triaryl-1,3,5-triazinanes was realized in the presence of chiral N,N′-dioxide–Ni(II) or Mg(II) complex. A variety of optically active β-amino compounds with all-carbon quaternary stereocenters were obtained in good yields with excellent enantioselectivities. A possible transition state was proposed based on these experiments and previous reports.

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A N,N′-dioxide/Mg(OTf)2 complex catalyzed enantioselective α-addition of isocyanides to alkylidene malonates

Weiwei Luo, Xiao Yuan, Lili Lin, Pengfei Zhou, Xiaohua Liu* and Xiaoming Feng*

Chem. Sci., 2016, 7, 4736-4740

DOI: 10.1039/C6SC00689B

A highly efficient catalytic asymmetric α-addition of isocyanides to alkylidene malonates was accomplished. The process was based on the utilization of a chiral N,N′-dioxide/MgII catalyst, delivering a variety of 2-alkyl-5-aminooxazoles in up to 99% yield and 96% ee under mild reaction conditions. Besides, a chiral imide and dipeptide could be easily obtained by ring-opening of the oxazole product, both of which are important structural motifs for many biologically active compounds. Based on the experimental investigations and previous work, a possible transition state model was proposed.

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Asymmetric [3 + 2] cycloaddition of donor–acceptor aziridines with aldehydes via carbon–carbon bond cleavage

Yuting Liao, Xiaohua Liu*, Yu Zhang, Yali Xu, Yong Xia, Lili Lin and Xiaoming Feng*  

Chem. Sci., 2016, 7, 3775-3779 
DOI: 10.1039/C5SC04151A 

An enantioselective [3 + 2] annulation of donor–acceptor aziridines with aldehydes has been realized using a Nd(OTf)3/N,N′-dioxide/LiNTf2 catalyst system, providing various chiral cis-1,3-oxazolidines in moderate to good yields with high levels of stereocontrol. A relay catalytic process is proposed where LiNTf2 promotes the formation of azomethine ylide intermediates, and a chiral Nd(III)–N,N′-dioxide complex accelerates the asymmetric cycloaddition.

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Nickel(II)-catalyzed enantioselective cyclopropanation of 3-alkenyl-oxindoles with phenyliodonium ylide via free carbene

Jing Guo, Yangbin Liu, Xiangqiang Li, Xiaohua Liu*, Lili Lin and Xiaoming Feng*

Chem. Sci., 2016, 7, 2717-2721 
DOI: 10.1039/C5SC03658E 

A chiral Lewis acid-promoted enantioselective cyclopropanation using phenyliodonium ylide as the carbene precursor was developed. A variety of spirocyclopropane-oxindoles with contiguous tertiary and all carbon quaternary centers were obtained in excellent outcomes (up to 99% yield, >19:1 d.r., up to 99% ee). EPR spectroscopy study supported a stepwise biradical mechanism.

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Professor Feng Says:


Chemical Science is one of the most excellent and  influential chemistry journals. We are glad that our research work could be rapidly visible to peers via such a free, open-access way. And we are grateful for all the support and feedback provided by the editorial board of chemical science, the reviewers, and the readers. I believe that Chemical Science will showcase more significant research works in a new year.  

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