药明生物与Vir Biotechnology针对新型冠状病毒抗体达成全球研发合作

WuXi Biologics and Vir Biotechnology Announce Collaboration for Global Development of Antibodies to Treat COVID-19

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美国，旧金山

中国，上海

2020年2月25日

全球领先的开放式生物制药技术平台公司药明生物（WuXi Biologics, 2269.HK）与生物技术公司Vir Biotechnology（以下简称Vir，纳斯达克股票代码：VIR）今日宣布，双方针对治疗新型冠状病毒肺炎（COVID-19）的全人单克隆抗体开发和生产达成一项合作协议。COVID-19是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的疾病。

根据协议条款，双方将共同推进Vir治疗COVID-19的领先抗体的临床开发、生产及商业化进程。药明生物将支持抗体细胞系开发、工艺和制剂开发以及临床开发早期生产。一旦这些抗体获得监管机构批准，药明生物将有权在大中华区商业化相关产品，全球其他市场的商业化权利则归Vir所有。

Vir从感染SARS的幸存者体内成功分离及鉴定出多个结合SARS-CoV-2的单克隆抗体，正进一步研究以确定这些抗体或其它可识别的抗体能够有效治疗和/或预防SARS-CoV-2。

“我们非常清楚迅速响应对于抗击COVID-19的重要性，”Vir首席执行官George A. Scangos博士表示，“如果能够开发出有效的抗体疗法，与药明生物合作将最大程度地加快该研发进展，及早战胜这一全球疾病挑战。”

“药明生物和Vir一致认为推进COVID-19抗体进入临床应用，早日惠及全球患者已迫在眉睫。凭借国际领先的生物医药开发平台和健全强大的全球生物药供应网络，我们将在加速COVID-19抗体疗法开发和生产进程中贡献独特力量，”药明生物首席执行官陈智胜博士表示，“此次合作再次表明药明生物正携手全球生物技术公司加快生物药开发进程，造福全球病患。”

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关于Vir抗体技术平台

Vir强大的抗体技术平台主要基于未感染或感染治愈人群所拥有的特殊天然免疫反应。该平台用于鉴定幸存者体内的稀有抗体，这些抗体有可能通过直接中和病原体和刺激免疫系统来治疗及预防快速进化和/或未有治疗方法的病原体。Vir抗体技术平台利用工程技术增强全人源抗体的治疗潜力，已成功应用于鉴别和开发针对埃博拉病毒（mAb114，目前应用于刚果民主共和国）、乙型肝炎病毒、甲型流感、疟疾等其他疾病的抗体。

关于Vir Biotechnology

Vir Biotechnology是一家处于临床阶段的生物技术公司，专注于利用免疫学洞见和前沿科技开发治疗和预防严重传染病的免疫疗法。Vir建立了四大技术平台，通过探索天然免疫过程的关键步骤设计刺激和增强免疫系统。公司目前五大候选产品线涵盖乙肝病毒、甲型流感、人类免疫缺陷病毒和结核病领域。

如需更多信息，请访问：www.vir.bio。

关于药明生物

药明生物（股票代码：2269.HK）作为一家香港上市公司，是全球领先的开放式、一体化生物制药能力和技术赋能平台。公司为全球生物制药公司和生物技术公司提供全方位的端到端研发服务，帮助任何人、任何公司发现、开发及生产生物药，实现从概念到商业化生产的全过程，加速全球生物药研发进程，降低研发成本，造福病患。截至2019年6月30日，在药明生物平台上研发的综合项目达224个，包括106个处于临床前研究阶段，102个在临床早期（I期，II期）阶段，15个在后期临床（III期）以及1个在商业化生产阶段。预计到2022年，公司在中国、爱尔兰、新加坡、美国规划的生物制药生产基地合计产能将超过28万升，这将有力确保公司通过健全强大的全球供应链网络为客户提供符合全球质量标准的生物药。

如需更多信息，请访问：www.wuxibiologics.com.cn。

WuXi Biologics and Vir Biotechnology Announce Collaboration for Global Development of Antibodies to Treat COVID-19

SAN FRANCISCO

SHANGHAI

Feb 25, 2020

WuXi Biologics ("WuXi Bio") (2269.HK), a leading global open-access biologics technology platform company offering end-to-end solutions for biologics discovery, development and manufacturing, and Vir Biotechnology, Inc. ("Vir") (Nasdaq: VIR) today announced a development and manufacturing collaboration to advance and produce human monoclonal antibodies for the potential treatment of Coronavirus Disease 2019 (COVID-19), a disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).

 

Under the terms of the agreement, the companies will work together on the clinical development, manufacturing, and commercialization of Vir’s proprietary antibodies. WuXi Biologics will conduct cell-line development, process and formulation development, and initial manufacturing for clinical development. If the antibodies receive regulatory approvals, WuXi Biologics has the rights to commercialize therapies in Greater China, and Vir has the rights to commercialize therapies in all other markets worldwide.

 

Vir has identified a number of monoclonal antibodies (mAbs) that bind to SARS-CoV-2. These antibodies were isolated from individuals who had survived a Severe Acute Respiratory Syndrome (SARS) infection. The company is conducting research to determine if its antibodies, or additional antibodies that it may be able to identify, can be effective as treatment and/or prophylaxis against SARS-CoV-2.

“We are acutely aware of the importance of moving rapidly in response to COVID-19,” said George A. Scangos, Ph.D., CEO of Vir Biotechnology. “In the event that we are in a position to develop an antibody therapy, our agreement with WuXi Biologics enables us to accelerate advancement against this global threat.”

“Both WuXi Biologics and Vir felt the great urgency to develop antibodies to treat global patients provided they work in the clinic. Our state-of-the-art technology platform and robust global-quality supply network make us uniquely qualified in expediting the development and manufacturing of these potential treatments," commented Chris Chen,  Ph.D., CEO of WuXi Biologics. "Once again WuXi Biologics is collaborating with global biotech companies such as Vir to expedite biologics development to benefit patients worldwide."

About Vir’s Antibody Platform

Vir has a robust method for capitalizing on unusually successful immune responses naturally occurring in people who are protected from, or have recovered from, infectious diseases. The platform is used to identify rare antibodies from survivors that have the potential to treat and prevent rapidly evolving and/or previously untreatable pathogens via direct pathogen neutralization and immune system stimulation. Vir engineers the fully human antibodies that it discovers to enhance their therapeutic potential. This platform has been used to identify and develop antibodies for pathogens including Ebola (mAb114, currently in use in the Democratic Republic of Congo), hepatitis B virus, influenza A, malaria, and others.

About Vir Biotechnology

Vir Biotechnology is a clinical-stage immunology company focused on combining immunologic insights with cutting-edge technologies to treat and prevent serious infectious diseases. Vir has assembled four technology platforms that are designed to stimulate and enhance the immune system by exploiting critical observations of natural immune processes. Its current development pipeline consists of five product candidates targeting hepatitis B virus, influenza A, human immunodeficiency virus and tuberculosis. For more information, please visit www.vir.bio.

About WuXi Biologics

WuXi Biologics (stock code: 2269.HK), a Hong Kong-listed company, is a leading global open-access biologics technology platform offering end-to-end solutions to empower organizations to discover, develop and manufacture biologics from concept to commercial manufacturing. Our company history and achievements demonstrate our commitment to providing a truly ONE-stop service offering and strong value proposition to our global clients. As of June 30, 2019, there were a total of 224 integrated projects, including 106 projects in pre-clinical development stage, 102 projects in early-phase (phase I and II) clinical development, 15 projects in late-phase (phase III) development and one project in commercial manufacturing. With total estimated capacity for biopharmaceutical production planned in China, Ireland, Singapore, and the U.S. exceeding 280,000 liters by 2022, we will provide our biomanufacturing partners with a robust and premier-quality global supply chain network. For more information on WuXi Biologics, please visit www.wuxibiologics.com.

媒体联系 Media Contact：
  药明生物 WuXi Biologics
  黄可博士 Kevin Huang PhD
  [phone]
  [e-mail]

注：本信息不构成药明生物的信息披露或投资建议