《纳米研究》2018年第10期目录

From: Nano Research NanoResearch

Nano Research

Editorial

The inaugural Nano Research Young Innovators (NR45) Award in nanobiotechnology

Zhen Gu^1,* and Hongjie Dai^2,*

¹ University of California, Los Angeles, USA

² Stanford University, USA

4931–4935

Review Articles

Inorganic nanoparticles and the microbiome

Kunyu Qiu, Phillip G. Durham, and Aaron C. Anselmo^*

University of North Carolina at Chapel Hill, USA

The human microbiota is routinely exposed to the inorganic nanoparticles present in consumer goods such as clothing, sunscreen, toothpaste, and foods. Here, we review current literature describing the effect of exposure to inorganic nanoparticles on the microbiome.

4936–4954

Scavenging of reactive oxygen and nitrogen species with nanomaterials

Carolina A. Ferreira, Dalong Ni^*, Zachary T. Rosenkrans, and Weibo Cai^*

University of Wisconsin-Madison, USA

Reactive oxygen and nitrogen species are implicated in various diseases. Herein, we review the intrinsic antioxidant properties, radical-scavenging mechanisms, and in vivo applications of several types of nanoparticles.

4955–4984

Strategies to improve micelle stability for drug delivery

Yang Lu, Ershuai Zhang, Jianhai Yang, and Zhiqiang Cao^*

Wayne State University, USA

Different strategies to improve micelle stability were reviewed in this work. Specific examples with improved drug delivery efficacy owing to enhanced micelle stability were illustrated.

4985–4998

Advances in targeted nanotherapeutics: From bioconjugation to biomimicry

Danielle M. Valcourt¹, Jenna Harris¹, Rachel S. Riley¹, Megan Dang¹, Jianxin Wang¹, and Emily S. Day^1,2,*

¹ University of Delaware, USA

² Helen F. Graham Cancer Center & Research Institute, USA

This review provides insight into the benefits and limitations of two types of targeted nanoparticle systems under investigation for cancer therapy: bioconjugated nanoparticles and biomimetic nanoparticles.

4999–5016

Multifunctional nucleic acid nanostructures for gene therapies

Jianbing Liu¹, Zhengang Wang¹, Shuai Zhao^1,2, and Baoquan Ding^1,2,*

¹National Center for Nanoscience and Technology, China

²University of Chinese Academy of Sciences, China

Nucleic acid nanostructures have been rationally designed as delivery vehicles for gene therapies based on RNA interference, CRISPR-Cas9 genome editing, gene expression, or CpG-based immunostimulation.

5017–5027

In situ polymerization on biomacromolecules for nanomedicines

Xiangqian Jia, Luyao Wang, and Juanjuan Du^*

Tsinghua University, China

While holding vast promise for the treatment of many disorders, biopharmaceuticals still face critical challenges. In situ polymerization provides an appealing and promising platform to improve the pharmacological characteristics of biopharmaceuticals.

5028–5048

Biomedical applications of magneto-responsive scaffolds

Adedokun A. Adedoyin and Adam K. Ekenseair^*

Northeastern University, USA

This review paper highlights the theory, fabrication and increasing use of magnetic nanoparticles to create biomaterials that are responsive to external magnetic fields for applications in drug delivery, tissue regeneration and artificial muscles.

5049–5064

Nano functional neural interfaces

Yongchen Wang¹, Hanlin Zhu², Huiran Yang^1,3, Aaron D. Argall¹, Lan Luan², Chong Xie^2,*, and Liang Guo^1,*

¹ The Ohio State University, USA

² The University of Texas at Austin, USA

³ Nanjing Tech University, China

Engineered functional neural interfaces serve as essential abiotic– biotic transducers between an engineered system and the nervous system. This review covers the exciting developments and applications of functional neural interfaces that rely on nano-electrodes, nanotransducers, or bionanotransducers to establish an interface with the nervous system.

5065–5106

Plenty more room on the glass bottom: Surface functionalization and nanobiotechnology for cell isolation

Ali Ansari^1,* and P. I. Imoukhuede^2,*

¹ University of Illinois at Urbana-Champaign, USA

² Washington University in St. Louis, USA

Modifying surfaces using surface functionalization has recently become much more commonplace, as it enables adaptive or responsive surfaces to be created for more complex testing modalities and biological applications. In this review, we discuss the many applications of surface functionalization techniques to both cell capture and cell isolation modalities, to provide expand the toolset for researchers who would like to adopt them.

5107–5129

High-density lipoprotein mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases

Song Ih Ahn, Hyun-Ji Park, Jiwon Yom, Taeyoung Kim, and Yong Tae Kim^*

Georgia Institute of Technology, USA

This review introduces the heterogeneous characteristics and biological functions of high-density lipoproteins (HDLs), highlights the current representative applications of HDL mimetic nano-therapeutics for cardiovascular and neurodegenerative diseases, and discusses the current challenges and future perspective.

5130–5143

Advances in nanomaterials for brain microscopy

Jackson T. Del Bonis-O’Donnell¹, Linda Chio¹, Gabriel F. Dorlhiac¹, Ian R. McFarlane¹, and Markita P. Landry^1,2,3,*

¹ University of California, Berkeley, USA

² Innovative Genomics Institute (IGI), USA

³ Chan-Zuckerberg Biohub, USA

Nanomaterials are providing new insights into the structure and function of the brain. In this review, we summarize the different techniques used in optical microscopy and discuss recent advances in nanomaterials, which are enabling new methods for visualizing the living brain.

5144–5172

Development of mRNA vaccines and their prophylactic and therapeutic applications

Kyuri Lee, Minjeong Kim, Yunmi Seo, and Hyukjin Lee^*

Ewha Womans University, Republic of Korea

In this article, the recent progresses of messenger RNA (mRNA) vaccines for applications in prophylactic and therapeutic vaccines are explained. It provides an overview of two types of mRNA vaccines (conventional mRNA vaccines, self-amplifying mRNA vaccines) and their prophylactic applications to prevent future virus infections. In addition, therapeutic applications of mRNA vaccines in cancer immunotherapy are described with a brief introduction to cancer immunotherapy.

5173–5192

Current taxane formulations and emerging cabazitaxel delivery systems

Boyang Sun, Robert M. Straubinger, and Jonathan F. Lovell^*

University at Buffalo, State University of New York, USA

Although first-generation taxanes (i.e., paclitaxel and docetaxel) have sparked broad interest in a variety of promising delivery vehicles, fewer have yet been developed for cabazitaxel, second generation taxane. This review summarizes several clinical-stage approaches for taxane formulation, and recent efforts to develop novel cabazitaxel delivery systems.

5193–5218

Functionalization of silica nanoparticles for nucleic acid delivery

Rimpei Kamegawa, Mitsuru Naito, and Kanjiro Miyata^*

The University of Tokyo, Japan

This review discusses the functionalization and performance of silica nanoparticles for nucleic acid delivery with respect to loading and programmed release of nucleic acids, active targeting, endosome escape, and biocompatibility.

5219–5239

Cell-based drug delivery systems for biomedical applications

Teng Li, He Dong, Can Zhang^*, and Ran Mo^*

China Pharmaceutical University, China

This review presents recent advances in biomedical applications of cell-based drug delivery systems with a focus on drug delivery, tissue engineering, bioimaging, and disease treatment.

5240–5257

Development of optical nanoprobes for molecular imaging of reactive oxygen and nitrogen species

Xu Zhen and Kanyi Pu^*

Nanyang Technological University, Singapore

This review summarizes the development of optical nanoprobes that emit near-infrared (NIR) fluorescent, upconversion luminescent (UCL), chemiluminescent (CL), or photoacoustic (PA) signals for molecular imaging of reactive oxygen and nitrogen species (RONS) in living systems.

5258–5280

Biomedical applications of mRNA nanomedicine

Qingqing Xiong^1,2, Gha Young Lee¹, Jianxun Ding¹, Wenliang Li^1,3, and Jinjun Shi^1,*

¹ Harvard Medical School, USA

² Tianjin Medical University Cancer Institute & Hospital, China

³ Jilin Medical University, China

Along with the development of chemical modification strategies and nanotechnology delivery platforms, messenger RNA (mRNA) nanomedicine has recently shown increasingly widespread biomedical applications including vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.

5281–5309

Design of synthetic materials for intracellular delivery of RNAs: From siRNA-mediated gene silencing to CRISPR/ Cas gene editing

Jason B. Miller and Daniel J. Siegwart^*

University of Texas Southwestern Medical Center, USA

This review describes the design of synthetic nanomaterials with clinical utility to deliver RNA cargos including small RNA (siRNA/ miRNA), messenger RNA, and RNAs for non-viral clustered regularly interspaced palindromic repeat (CRISPR)/Cas gene editing.

5310–5337

Recent advances in mRNA vaccine delivery

Lu Tan and Xun Sun^*

Sichuan University, China

Appropriate delivery systems can improve the limited stability, poor translation efficiency, and cell targeting of messenger RNA (mRNA) vaccines.

5338–5354

Engineering cancer vaccines using stimuli-responsive biomaterials

Yu Zhao, Yugang Guo, and Li Tang^*

École polytechnique fédérale de Lausanne (EPFL), Switzerland

This mini review article summarizes the recent advances in applying stimuli-responsive biomaterials for cancer vaccine delivery. Various stimuli-responsive cancer vaccines for enhanced lymph node targeting and antigen cross-presentation are reviewed and discussed.

5355–5371

Nanobiotechnology: 1D nanomaterial building blocks for cellular interfaces and hybrid tissues

Haitao Liu^1,2, Bilal Haider¹, Holden R. Fried¹, Jie Ju¹, Olurotimi Bolonduro¹, Vineeth Raghuram¹, and Brian P. Timko^1,*

¹ Tufts University, USA

² China University of Geosciences, China

We review one-dimensional (1D) nanomaterials and how they interface with biological systems at various levels of complexity to modulate or monitor cellular function and achieve hybrid tissues.

5372–5399

Temperature-responsive polymers: Synthesis, properties, and biomedical applications

Shenglin Qiao^1,2 and Hao Wang^1,2,*

¹ National Center for Nanoscience and Technology, China

²University of Chinese Academy of Sciences, China

Here, we review the conventional and recently developed polymerization techniques employed for preparing temperature- responsive polymers, summarize various parameters that influence the phase transition behavior of the polymers, and finally demonstrate the potential applications of biocompatible temperature-responsive polymers in the biomedical field.

5400–5423

Phototriggered targeting of nanocarriers for drug delivery

Yafei Li, Yaming Zhang, and Weiping Wang^*

The University of Hong Kong, Hong Kong, China

Enhanced targeted drug delivery can be achieved through photo-triggered targeting by three mechanisms: targeting ligand activation, particle size reduction, and blood vessel disruption.

5424–5438

Plasmonic molecular assays: Recent advances and applications for mobile health

Tao Yu and Qingshan Wei^*

North Carolina State University, USA

This thematic article of Nano Research highlights recent progress in plasmonics-enhanced molecular assays based on the interplay of surface plasmons with various biological species, as well as the applications of these assays in point-of-care diagnostics.

5439–5473

Nanoformulation of metal complexes: Intelligent stimuli- responsive platforms for precision therapeutics

Ming Hu¹, Xiangzhao Ai¹, Zhimin Wang¹, Zhijun Zhang¹, Haolun Cheong¹, Wenmin Zhang^1,2, Jun Lin³, Juan Li², Huanghao Yang², and Bengang Xing^1,2,*

¹ Nanyang Technological University, Singapore

² Fuzhou University, China

³ Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China

Nanoformulation of metal complexes involves designing of intelligent platforms that respond to environmental stimuli (e.g., pH-gradient, redox conditions, enzyme activation, light irradiation, and magnetic field manipulation) for obtaining precision therapeutics.

5474–5498

Recent progress in background-free latent fingerprint imaging

Yingqian Wang, Jie Wang, Qinqin Ma, Zhihao Li, and Quan Yuan^*

Wuhan University, China

This review is organized around background-free latent fingerprint (LFP) imaging based on the difference in optical properties between contrast agents and background compounds.

5499–5518

PEGylation of therapeutic oligonucletides: From linear to highly branched PEG architectures

Xueguang Lu and Ke Zhang^*

Northeastern University, USA

We review recent developments in PEGylated oligonucleotides for therapeutic applications, with a focus on comparing the strengths and limitations of different poly(ethylene glycol) (PEG) architectures.

5519–5534

Delivery systems for theranostics in neurodegenerative diseases

Yan Li¹, Ruiyuan Liu^1,2, Weihong Ji^1,2, Yanhui Li¹, Linying Liu^1,2, and Xin Zhang^1,*

¹ Institute of Process Engineering, Chinese Academy of Sciences, China

² University of Chinese Academy of Sciences, China

This review describes the recent progress in delivery systems, including the use of lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, and exosomes for theranostics in neurodegenerative diseases.

5535–5555

Research Articles

Reversible hydrogels with tunable mechanical properties for optically controlling cell migration

Xin Wu¹, Wenmao Huang¹, Wen-Hao Wu², Bin Xue¹, Dongfang Xiang¹, Ying Li³, Meng Qin¹, Fei Sun⁴, Wei Wang^1,*, Wen-Bin Zhang^2,*, and Yi Cao^1,*

¹ Nanjing University, China

² Peking University, China

³ Nanjing University of Information Science & Technology, China

⁴ The Hong Kong University of Science and Technology, Hong Kong, China

Photo-responsive hydrogels with spatiotemporally tunable mechanical properties were engineered through light controllable association/ dissociation of the fluorescent protein Dronpa145N. Such hydrogels, with programmable mechanical history and spatial distribution, may serve as an ideal model system to better understand complex cellular functions.

5556–5565

Self-assembly of Human Galectin-1 via dual supramolecular interactions and its inhibition of T-cell agglutination and apoptosis

Wenjing Qi¹, Yufei Zhang¹, Zdravko Kochovski², Jue Wang¹, Yan Lu^2,3, Guosong Chen^1,*, and Ming Jiang¹

¹ Fudan University, China

²Helmholtz-Zentrum Berlin für Materialien und Energie, Germany

³ University of Potsdam, Germany

Human Galectin was found to be able to form protein microribbons by protein–carbohydrate interactions and the dimerization of Rhodamine B (RhB). These protein microribbons could multivalently and dynamically compete with accommodate the binding between Human Galectin-1 (Gal-1) and cell receptors and inhibit T-cell agglutination and apoptosis.

5566–5572

Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs

Zhiyuan Fan¹, Peter Y. Li¹, Junjie Deng^1,2, Stephen C. Bady¹, and Hao Cheng^1,*

¹ Drexel University, USA

² Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, China

Incorporation of therapeutic-releasing nanoparticles into biomaterial scaffolds has broad applications in tissue regeneration and immune modulation, but may induce excessive inflammatory and foreign body responses to scaffold constructs, limiting their applications. We report a new strategy to harness the natural biocompatibility of cell membranes to eliminate acute inflammatory responses by coating nanoparticle surfaces with red blood cell membranes.

5573–5583

Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery

Jonathan Wang, Christopher Poon, Deborah Chin, Sarah Milkowski, Vivian Lu, Kenneth R. Hallows, and Eun Ji Chung^*

University of Southern California, USA

Kidney-targeting multimodal micelles demonstrate enhanced accumulation compared to untargeted controls. Analysis of nano-particle distribution show tubular cell colocalization within the nephron of the kidney.

5584–5595

Co-delivery of mRNA and SPIONs through amino-ester nanomaterials

Xiao Luo, Weiyu Zhao, Bin Li, Xinfu Zhang, Chengxiang Zhang, Anna Bratasz, Binbin Deng, David W. McComb, and Yizhou Dong^*

The Ohio State University, USA

Messenger RNA (mRNA) and superparamagnetic iron oxide nanoparticles (SPIONs) were co-encapsulated into amino-ester nanomaterials, which displayed dual functions both in vitro and in vivo.

5596–5603

Flexible and biocompatible nanopaper-based electrode arrays for neural activity recording

Yichuan Guo^1,2, Zhiqiang Fang³, Mingde Du^1,2, Long Yang⁴, Leihou Shao^1,2, Xiaorui Zhang^1,2, Li Li^1,2, Jidong Shi^1,2, Jinsong Tao³, Jinfen Wang^1,2, Hongbian Li^1,2,*, and Ying Fang^1,2,5,*

¹ National Center for Nanoscience and Technology, China

² University of Chinese Academy of Sciences, China

³South China University of Technology, China

⁴ University of California, Los Angeles, USA

⁵CAS Center for Excellence in Brain Science and Intelligence Technology, China

Flexible and biocompatible neural electrode arrays based on a nanopaper substrate have been developed. These electrode arrays exhibit high sensitivity and stability in long-term brain activity recording.

5604–5614

The shape effect of reconstituted high-density lipoprotein nanocarriers on brain delivery and Aβ clearance

Huahua Song¹, Xinyi Ma¹, Jianrong Xu¹, Qingxiang Song¹, Meng Hu¹, Xiao Gu¹, Qian Zhang¹, Lina Hou¹, Lepei Chen¹, Yukun Huang², Ping Yu¹, Dayuan Wang¹, Gan Jiang¹, Meng Huang¹, Jun Chen², Hongzhuan Chen^1,*, and Xiaoling Gao^1,*

¹ Shanghai Jiao Tong University, China

²Fudan University, China

Here, we constructed two discoidal reconstituted high-density lipoprotein (rHDL) nanocarriers (d-rHDL and d-GM1-rHDL) and two spherical rHDL nanocarriers (s-rHDL and s-GM1-rHDL) and for the first time demonstrated the shape effect of rHDL nanocarriers on their brain delivery and amyloid β clearance capacity.

5615–5628

Traditional Chinese medicine molecule-assisted chemical synthesis of fluorescent anti-cancer silicon nanoparticles

Xiaoyuan Ji, Daoxia Guo, Bin Song, Sicong Wu, Binbin Chu, Yuanyuan Su, and Yao He^*

Soochow University, China

A novel traditional Chinese medicine (TCM)-assisted chemical synthetic strategy is introduced for the one-pot synthesis of small- sized water-dispersed anti-cancer (AC)-silicon nanoparticles (SiNPs), which simultaneously possess robust fluorescence, excellent storage stability, and more interestingly, intrinsic anti-cancer efficacy with good selectivity towards cancer cells. Furthermore, the as-prepared AC-SiNPs are further employed for synergistic fluorescence bioimaging and treatment of tumors.

5629–5641

Polyplex interaction strength as a driver of potency during cancer immunotherapy

Shannon J. Tsai¹, James I. Andorko¹, Xiangbin Zeng¹, Joshua M. Gammon¹, and Christopher M. Jewell^1,2,3,4,*

¹ University of Maryland, USA

² Maryland VA Health Care System, USA

³ University of Maryland Medical School, USA

⁴Marlene and Stewart Greenebaum Cancer Center, USA

The interaction strength within polyplexes between a molecular adjuvant (CpG) and a degradable polycation (poly(-amino ester), PBAE) is dependent on the ratio of these components during assembly. The interaction strength impacts the uptake and processing of the CpG, and the resulting immune response during activation of antigen presenting cells, expansion of tumor-specific T cells, and tumor immunotherapy.

5642–5656

NIR-II light activated photodynamic therapy with protein- capped gold nanoclusters

Qian Chen¹, Jiawen Chen¹, Zhijuan Yang¹, Lin Zhang², Ziliang Dong¹, and Zhuang Liu^1,*

¹ Soochow University, China

²The First Affiliated Hospital of Soochow University, China

A new type of photosensitizing nano-agent that simultaneously enables in vivo fluorescence imaging, tumor hypoxia relief, and the second near-infrared window (NIR-II) light-induced in vivo photodynamic therapy (PDT) of cancer was developed.

5657–5669

Curcumin-loaded polymeric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischemic encephalopathy

Andrea Joseph, Thomas Wood, Chih-Chung Chen^†, Kylie Corry, Jessica M. Snyder, Sandra E. Juul, Pratik Parikh, and Elizabeth Nance^*

University of Washington, USA

^† Present address: University of Illinois at Urbana-Champaign, USA

Curcumin-loaded brain-penetrating nanoparticles can cross the impaired blood-brain barrier following systemic administration in a neonatal hypoxia-ischemia rat model. The brain-penetrating nanoparticles localize in regions of injury and release curcumin to provide a neuroprotective effect, expanding the number of clinically-relevant therapeutic interventions for the treatment of neonatal hypoxic-ischemic encephalopathy.

5670–5688

Polymersomes scalably fabricated via flash nano-precipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration

Sean D. Allen¹, Yu-Gang Liu¹, Sharan Bobbala¹, Lei Cai², Peter I. Hecker², Ryan Temel², and Evan A. Scott^1,*

¹ Northwestern University, USA

² University of Kentucky, USA

Poly(ethylene glycol)-block-poly(propylene sulfide) (PEG-bl-PPS) polymersomes formed by flash nanoprecipitation were found to be non-toxic after repeated intravenous administration in non-human primates. Polymersomes were taken up by antigen-presenting cell subsets in the liver, kidneys, and spleen of treated cynomolgus monkeys.

5689–5703

Engineering subcellular-patterned biointerfaces to regulate the surface wetting of multicellular spheroids

Luying Wang^1,3, Pingqiang Cai⁴, Jing Luo^2,3, Feilong Zhang^1,3, Jian Liu², Yupeng Chen^2,3, Zhongpeng Zhu^2,3, Yongyang Song^2,3, Bingquan Yang², Xi Liu^2,3, Xiaodong Chen⁴, and Shutao Wang^2,3,*

¹Institute of Chemistry, Chinese Academy of Sciences, China

² Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, China

³ University of Chinese Academy of Sciences, China

⁴ Nanyang Technological University, Singapore

Subcellular-patterned biointerfaces were employed to inhibit the surface wetting of multicellular spheroids.

5704–5715

Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs

Wei Jiang¹, Jilong Wang¹, Jinbin Yang², Zhiwei He¹, Zhenhui Hou¹, Yingli Luo¹, Li Wang¹, Jing Liu¹, Houbing Zhang¹, Yangyang Zhao¹, Guoqing Zhang¹, Fang Huang¹, Xuechang Zhou², Lifeng Yan^1,*, Xianzhu Yang^3,*, Yucai Wang^1,*, and Jun Wang³

¹ University of Science and Technology of China, China

²Shenzhen University, China

³South China University of Technology, China

A transactivator of transcription (TAT)-presenting nanomedicine, apart from improving tumor accumulation and cellular uptake, can simultaneously enhance tumor retention and promote nuclear translocation of the encapsulated platinum prodrugs, and thus improve therapeutic efficacy.

5716–5734

A facile fabrication route for binary transition metal oxide-based Janus nanoparticles for cancer theranostic applications

M. Zubair Iqbal¹, Wenzhi Ren¹, Madiha Saeed¹, Tianxiang Chen¹, Xuehua Ma¹, Xu Yu¹, Jichao Zhang², Lili Zhang², Aiguo Li², and Aiguo Wu^1,*

¹Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, China

²Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China

A unique liquid-phase method was employed to fabricate Mn₃O₄- TiO₂/ZnO/Fe₃O₄multifunctional binary transition metal oxide-based Janus nanoparticles, using the concept of epitaxial growth and lattice mismatch among synthesized materials. These multifunctional Mn₃O₄-TiO₂ Janus nanoparticles enhance T1-weighted magnetic resonance imaging contrast in the heart, liver, and kidneys and show excellent tumor ablation in photodynamic therapy.

5735–5750

LiF@SiO₂ nanocapsules for controlled lithium release and osteoarthritis treatment

Trever Todd¹, Zhenhui Lu², Jinmin Zhao², Benjamin Cline¹, Weizhong Zhang¹, Hongmin Chen^1,3, Anil Kumar¹, Wen Jiang¹, Franklin West¹, Samuel Franklin¹, Li Zheng^2,*, and Jin Xie^1,*

¹ University of Georgia, USA

²The First Affiliated Hospital of Guangxi Medical University, China

³ Xiamen University, China

Controlled lithium delivery for efficient osteoarthritis therapy is described. We use a LiF nanocrystal as a lithium reservoir, silica coating to control the lithium release rate, and hyaluronic acid as the delivery medium. The sustained lithium release elicits broad inhibition of osteoarthritis-related catabolic markers, leading to effective protection of cartilage.

5751–5760

Selenium-functionalized metal-organic frameworks as enzyme mimics

Weiqiang Zhou^1,2, Hongfeng Li¹, Bin Xia¹, Wenlan Ji¹, Shaobo Ji², Weina Zhang¹, Wei Huang^1,*, Fengwei Huo^1,*, and Huaping Xu^2,*

¹ Nanjing Tech University (Nanjing Tech), China

² Tsinghua University, China

A general and facile method to fabricate efficient glutathione peroxidase (GPx) mimics has been developed by grafting selenium- containing molecules (phenylselenylbromide, PhSeBr) to a of Zr(IV)-based UiO-66-NH₂ framework. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. The high- efficiency GPx mimic metal-organic frameworks (MOFs) are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.

5761–5768

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