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Nature Materials NatMater资讯 2022-10-01

纳米粒子修饰的微型机器人用于治疗急性细菌性肺炎的体内抗生素递送

Biohybrid microrobots consisting of nanoparticle-modified microalgae are constructed for active drug delivery in the lungs. In an acute bacterial pneumonia model, the microrobots effectively reduce bacterial burden and lessen animal mortality.


Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia
Bioinspired microrobots capable of actively moving in biological fluids have attracted considerable attention for biomedical applications because of their unique dynamic features that are otherwise difficult to achieve by their static counterparts. Here we use click chemistry to attach antibiotic-loaded neutrophil membrane-coated polymeric nanoparticles to natural microalgae, thus creating hybrid microrobots for the active delivery of antibiotics in the lungs in vivo. The microrobots show fast speed (>110 µm s−1) in simulated lung fluid and uniform distribution into deep lung tissues, low clearance by alveolar macrophages and superb tissue retention time (>2 days) after intratracheal administration to test animals. In a mouse model of acute Pseudomonas aeruginosa pneumonia, the microrobots effectively reduce bacterial burden and substantially lessen animal mortality, with negligible toxicity. Overall, these findings highlight the attractive functions of algae–nanoparticle hybrid microrobots for the active in vivo delivery of therapeutics to the lungs in intensive care unit settings.


Preparation and structural characterization of the algae–nanoparticle hybrid microrobot (denoted as ‘algae-NP-robot’).


Fangyu Zhang, Jia Zhuang, Zhengxing Li, Hua Gong, Berta Esteban-Fernández de Ávila, Yaou Duan, Qiangzhe Zhang, Jiarong Zhou, Lu Yin, Emil Karshalev, Weiwei Gao, Victor Nizet, Ronnie H. Fang, Liangfang Zhang & Joseph Wang 

doi: 10.1038/s41563-022-01360-9
Article


超薄钇铁石榴石薄膜中的巨磁振子自旋导电

The authors report the observation of an enhanced magnon conductivity close to the two-dimensional transport regime in ultrathin yttrium iron garnet.


Giant magnon spin conductivity in ultrathin yttrium iron garnet films

Conductivities are key material parameters that govern various types of transport (electronic charge, spin, heat and so on) driven by thermodynamic forces. Magnons, the elementary excitations of the magnetic order, flow under the gradient of a magnon chemical potential in proportion to a magnon (spin) conductivity. The magnetic insulator yttrium iron garnet is the material of choice for efficient magnon spin transport. Here we report a giant magnon conductivity in thin yttrium iron garnet films with thicknesses down to 3.7 nm when the number of occupied two-dimensional subbands is reduced from a large number to a few, which corresponds to a transition from three-dimensional to two-dimensional magnon transport. We extract a two-dimensional magnon spin conductivity around 1 S at room temperature, comparable to the (electronic) conductivity of the high-mobility two-dimensional electron gas in GaAs quantum wells at millikelvin temperatures4. Such high conductivities offer opportunities to develop low-dissipation magnon-based spintronic devices.


Device layout.


X.-Y. Wei, O. Alves Santos, C. H. Sumba Lusero, G. E. W. Bauer, J. Ben Youssef & B. J. van Wees 

doi: 10.1038/s41563-022-01369-0
Letter


可用于机械致变色织物的固胆甾型液晶弹性体纤维

Robust cholesteric liquid crystal elastomer fibres with rapid and reversible mechanochromic responses are woven and sewn into garments to create smart clothing.


Robust cholesteric liquid crystal elastomer fibres for mechanochromic textiles

Mechanically responsive textiles have transformative potential in many areas from fashion to healthcare. Cholesteric liquid crystal elastomers have strong mechanochromic responses that offer attractive opportunities for such applications. Nonetheless, making liquid crystalline elastomer fibres suitable for textiles is challenging since the Plateau–Rayleigh instability tends to break up precursor solutions into droplets. Here, we report a simple approach that balances the viscoelastic properties of the precursor solution to avoid this outcome and achieve long and mechanically robust cholesteric liquid crystal elastomer filaments. These filaments have fast, progressive and reversible mechanochromic responses, from red to blue (wavelength shift of 155 nm), when stretched up to 200%. Moreover, the fibres can be sewed into garments and withstand repeated stretching and regular machine washing. This approach and resulting fibres may be useful for applications in wearable technology and other areas benefiting from autonomous strain sensing or detection of critically strong deformations.


CLCE fibre production from oligomeric precursor liquid.


Yong Geng, Rijeesh Kizhakidathazhath & Jan P. F. Lagerwall 

doi: 10.1038/s41563-022-01355-6
Article


HfTe5中的拓扑Lifshitz转变和一维Weyl模态

The manuscript reports on the experimental observation of a Lifshitz transition in a topological insulator HfTe5 subject to a strong magnetic field, which results in the formation of topological one-dimensional Weyl modes in the bulk of a three-dimensional material.


Topological Lifshitz transition and one-dimensional Weyl mode in HfTe5
Landau band crossings typically stem from the intra-band evolution of electronic states in magnetic fields and enhance the interaction effect in their vicinity. Here in the extreme quantum limit of topological insulator HfTe5, we report the observation of a topological Lifshitz transition from inter-band Landau level crossings using magneto-infrared spectroscopy. By tracking the Landau level transitions, we demonstrate that band inversion drives the zeroth Landau bands to cross with each other after 4.5 T and forms a one-dimensional Weyl mode with the fundamental gap persistently closed. The unusual reduction of the zeroth Landau level transition activity suggests a topological Lifshitz transition at 21 T, which shifts the Weyl mode close to the Fermi level. As a result, a broad and asymmetric absorption feature emerges due to the Pauli blocking effect in one dimension, along with a distinctive negative magneto-resistivity. Our results provide a strategy for realizing one-dimensional Weyl quasiparticles in bulk crystals.


Schematic plot of proposed magnetic-field-driven phase transitions.


Wenbin Wu, Zeping Shi, Yuhan Du, Yuxiang Wang, Fang Qin, Xianghao Meng, Binglin Liu, Yuanji Ma, Zhongbo Yan, Mykhaylo Ozerov, Cheng Zhang, Hai-Zhou Lu, Junhao Chu & Xiang Yuan 

doi: 10.1038/s41563-022-01364-5
Article


调控绝缘体-金属转变的尖端诱导氢化

The authors realize local and reversible hydrogenation of VO2 using a Pt-coated scanning probe microscope tip and forming gas.


Manipulating the insulator–metal transition through tip-induced hydrogenation

Manipulating the insulator–metal transition in strongly correlated materials has attracted a broad range of research activity due to its promising applications in, for example, memories, electrochromic windows and optical modulators. Electric-field-controlled hydrogenation using ionic liquids and solid electrolytes is a useful strategy to obtain the insulator–metal transition with corresponding electron filling, but faces technical challenges for miniaturization due to the complicated device architecture. Here we demonstrate reversible electric-field control of nanoscale hydrogenation into VO2 with a tunable insulator–metal transition using a scanning probe. The Pt-coated probe serves as an efficient catalyst to split hydrogen molecules, while the positive-biased voltage accelerates hydrogen ions between the tip and sample surface to facilitate their incorporation, leading to non-volatile transformation from insulating VO2 into conducting HxVO2. Remarkably, a negative-biased voltage triggers dehydrogenation to restore the insulating VO2. This work demonstrates a local and reversible electric-field-controlled insulator–metal transition through hydrogen evolution and presents a versatile pathway to exploit multiple functional devices at the nanoscale.


IMT of VO2 thin films through hydrogenation.


Linglong Li, Meng Wang, Yadong Zhou, Yang Zhang, Fan Zhang, Yongshun Wu, Yujia Wang, Yingjie Lyu, Nianpeng Lu, Guopeng Wang, Huining Peng, Shengchun Shen, Yingge Du, Zihua Zhu, Ce-Wen Nan & Pu Yu 

doi: 10.1038/s41563-022-01373-4
Letter


量子电子液体和相转变

A purely quantum electronic liquid on the surface of an electride crystal is reported.


Quantum electron liquid and its possible phase transition

Purely quantum electron systems exhibit intriguing correlated electronic phases by virtue of quantum fluctuations in addition to electron–electron interactions. To realize such quantum electron systems, a key ingredient is dense electrons decoupled from other degrees of freedom. Here, we report the discovery of a pure quantum electron liquid that spreads up to ~3 Å in a vacuum on the surface of an electride crystal. Its extremely high electron density and weak hybridization with buried atomic orbitals show the quantum and pure nature of the electrons, which exhibit a polarized liquid phase, as demonstrated by our spin-dependent measurement. Furthermore, upon enhancing the electron correlation strength, the dynamics of the quantum electrons change to that of a non-Fermi liquid along with an anomalous band deformation, suggestive of a transition to a hexatic liquid crystal phase. Our findings develop the frontier of quantum electron systems and serve as a platform for exploring correlated electronic phases in a pure fashion.


Evolution of pure 2D quantum electrons.


Sunghun Kim, Joonho Bang, Chan-young Lim, Seung Yong Lee, Jounghoon Hyun, Gyubin Lee, Yeonghoon Lee, Jonathan D. Denlinger, Soonsang Huh, Changyoung Kim, Sang Yong Song, Jungpil Seo, Dinesh Thapa, Seong-Gon Kim, Young Hee Lee, Yeongkwan Kim & Sung Wng Kim 

doi: 10.1038/s41563-022-01353-8
Article




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