【学术视频】爱思唯尔化学中国行-化学促进健康研讨会 | 加拿大阿尔伯塔大学厉良教授

图 | 厉良教授

题   目：Towards Near-Complete Metabolome Profiling of  Biological and clinical Systems: Analytical Method Development and Health Research Applications

报告人：厉良

单   位：University of Alberta

时   间：2019年3月25日

地   点：上海大学量子与分子结构国际研究中心

扫码观看精彩报告视频

报告摘要

New advances in analytical technologies such as genome sequencing have made a huge impact on health science research. The arrival of rapid DNA sequencing technology has significantly raised the bar on the requirement of performing proteome and metabolome analysis, ideally reaching the complete proteome and metabolome coverage. This presentation will focus on advances in metabolomics technology and its applications in health research. Metabolomics is a relatively newcomer of the omics family for large scale characterization of molecular features of a biological system. A key step in metabolomics is to perform relative quantification of metabolomic changes among different samples. High-coverage metabolome profiling will benefit research in systems biology and disease biomarker discovery, but is currently a challenging task. To increase coverage, traditionally, multiple analytical tools and methods are used to generate a combined metabolome data set. However, this approach requires heavy investment on equipment and high analytical skills and expertise. Even with the combined results, the overall metabolome coverage is still low, particularly for quantitative metabolite analysis. In this presentation, I will discuss a simple and robust platform for in-depth metabolome analysis based on chemical isotope labeling (CIL) liquid chromatography (LC) mass spectrometry (MS). I will discuss the research strategies behind the development of the instrumental platform and standardized workflows for sample preparation, sample analysis, data processing and results analysis. I will then use several examples of applications to showcase the CIL LC-MS platform for disease biomarker discovery research as well as biological studies.

....

个人简介

厉良，1989年加入阿尔伯塔大学，担任化学教授，生物化学兼职教授，分析化学领域的加拿大一级首席研究员。其目前积极开发新的代谢组学分析技术，并探索其在临床和生物医学研究中的应用。他的研究小组在开发高效同位素标记液质联用平台(LC-MS)上处于领先地位，该平台被用于对生物系统进行定量且全面的代谢组分析。

会议简介

跨学科研究已成为现代科研的必然趋势，来自不同领域的专家携手合作，共同应对研究挑战，推动社会发展进步。以人类健康为例，这个主题涉及理解生物学基础知识，开发更佳的诊断和治疗方法等多个领域，也需要化学家们的通力合作。Elsevier爱思唯尔化学中国行活动，于2019年3月开展两场“化学促进健康”研讨会，分别在上海大学和清华大学举行，旨在与您一起探讨化学能为人类健康所做的贡献。本次研讨会将涵盖疾病调查、药物生产、健康监测等多个主题，邀请您及对该话题有兴趣的同事一同参与。

END

为满足更多科研工作者的需求，蔻享学术陆续开通了各科研领域的微信交流群。进群请备注研究方向或科研领域。

扫码添加

更多精彩视频登陆网站

www.koushare.com

未经许可，禁止转载本页内容

转载授权请联系：

[e-mail]