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直播信息
报告题目
Functional polymers with designed molecular recognition
报告人
Prof. Lei Ye （Lund University）
报告时间
2022年4月25日（周一）15:00
主办方
电子科技大学材料与能源学院
直播二维码
报告人介绍
Prof. Lei Ye is full Professor and head of the Division of Pure and Applied Biochemistry, Lund University, Sweden. His research has been focused on functional polymers with molecular recognition capabilities, and applications of molecular recognition polymers for biochemical and bioengineering applications. The group of Lei Ye has pioneered a series of molecular imprinting methodologies, leading to numerous important contributions to biomimetic polymers and multifunctional materials. Lei Ye and his team has published over 140 research articles in international chemistry journals including Angew. Chem. Int. Ed., J. Am. Chem. Soc., Anal. Chem., Chem. Commun. Lei Ye has over 9000 citations with H-factor of 50.
报告摘要
Synthetic polymers with the capability of pre-defined molecular recognition have enormous potential in life science and biochemical applications. In our laboratory we use two synthetic strategies to develop functional polymers that are able to recognize biological molecules of very different sizes. The first strategy is to use molecular imprinting to create selective binding sites in crosslinked polymers, which are also named “plastic antibodies” due to their antibody-like molecular binding properties. Molecularly imprinted polymers have been integrated with different signal transduction systems to construct chemical sensors. To make molecular recognition sites accessible for large biological species, we have developed an interfacial molecular imprinting method using particle-stabilized emulsion (Pickering emulsion) as a synthetic platform. Using the interfacial imprinting method, molecularly imprinted polymers (MIPs) with pre-defined selectivity for proteins and cells have been realized. The second strategy that we use to engineer polymer structures is controlled (living) radical polymerization. We focus on developing smart polymers for recognition of carbohydrates and glycoproteins. By combining atom transfer radical polymerization (ATRP) with click chemistry, we develop a series of boronic acid polymers with defined ligand density and stimuli-responsive properties. The engineered boronic acid polymers and composites display selective recognition for carbohydrates and glycoproteins under physiological pH. Using nanoparticle-supported polymer brushes as a generic platform, purification of recombinant proteins with designed affinity tags has been demonstrated.