报告摘要：Drug delivery to the brain is a major challenge, because the brain possesses the blood-brain barrier (BBB), which prevents the penetration of most drugs into the brain. In this talk, I will introduce a serial of techniques established in my laboratory for drug delivery to the brain through locoregional, intravenous, or oral administration. I will give a few examples to show how these techniques can be utilized for delivery of therapeutic agents to the brain for treatment of brain cancer or stroke.
报告题目：Molecular Imaging, Nanobiotechnology, and Theranostics
报告摘要：The Molecular Imaging and Nanotechnology Laboratory at the University of Wisconsin - Madison (http://mi.wisc.edu/) is mainly focused on three areas: 1) development of multimodality molecular imaging agents; 2) nanobiotechnology and its biomedical applications; and 3) molecular therapy of cancer and various other diseases. In this talk, I will present our recent work on molecular imaging and image-guided drug delivery of cancer and other diseases with peptides, proteins, and a variety of nanomaterials. The primary imaging techniques used in these studies are positron emission tomography (PET), photoacoustic tomography (PAT), optical imaging, and magnetic resonance imaging (MRI). Some molecular targets that we have investigated are CD105 (i.e. endoglin), PD-1/PD-L1, CTLA-4, CD146, VEGFR, integrin αvβ3, among others. The nanomaterials that will be discussed in this presentation may include silica-based nanoparticles, DNA nanomaterials, nanovaccines, micelles, iron oxide nanoparticles, 2-D nanomaterials, hybrid nanomaterials, among others.