【直播】【BMEMat】新加坡国立大学刘斌 院士 学术报告
讲座名称:
Accelerating Biomedical Research through Materials Innovation
讲座时间:
2022年12月15日(星期四)16:00
报告嘉宾:
刘斌 院士
主办单位:
BMEMat
主持人:
梁兴杰研究员 国家纳米科学中心 (BMEMat 副主编,国家杰出青年基金获得者)
直播通道
蔻享学术直播间 |
报告人介绍
刘斌 院士
报告简介
The recent years have witnessed the fast grow of fluorogens with aggregation-induced emission characteristics (AIEgens) in biomedical research. In this talk, we summarize our recent AIE work in the development of new fluorescent bioprobes for biosensing and imaging. The simple design and fluorescence turn-on feature of the molecular AIE bioprobes offer direct visualization of specific analytes and biological processes in aqueous media with higher sensitivity and better accuracy than traditional fluorescence turn-off probes. The AIE dot probes with different formulations and surface functionalities show advanced features over quantum dots and small molecule dyes in noninvasive cancer cell detection, long term cell tracing, and vascular imaging. In addition, our recent discovery that AIEgens with high brightness and efficient reactive oxygen species generation in aggregate state further expanded their applications to image-guided cancer surgery and therapy. Combining the accurate prediction of material performance via first-principles calculations and Bayesian optimization-based active learning, we have realized a self-improving discovery system for high-performance photosensitizers, which can significantly accelerate the materials innovation for biomedical research.
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编辑:吴良秀
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