其他
RIBOTAC:开启RNA降解新时代
小结
[1]JESSICA A. BUSH et al. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansionin vitro and in vivo ALS models. SCIENCE TRANSLATIONAL MEDICINE(2021).[2] Matthew G. Costales et al. Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA. Cell Chemical Biology(2019).[3]Peiyuan Zhang et al. Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.JACS(2021).[4] Degrading disease-causing RNA in ALS(来源:Nature Reviews Drug Discovery)[5] Potential treatment for ALS,frontotemporal dementia targets RNA(来源:Scripps研究所)[6] RIBOTACs: Small Molecules Target RNAfor Degradation(来源:Cell Chemical Biology)[7] Small-molecule selectively destroys cancer-associated RNA(来源:C&EN)[8] Neuron | 孙疏影团队揭示RNA解螺旋酶DDX3X调节C9ORF72翻译的机制(来源:BioArt)[9] Expansion Therapeutics Raises $80 Million Series B Financing to Treat Neurodegenerative Diseases(来源:Expansion)
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