今日学术问题发现 | 山西医科大学贺婵婷等人论文数据图片出现多处重复
Author:
Chanting He,1,2,3,4,5 Xiaoyan Zhao,1,5 Yang Lei,1 Jisheng Nie,1 Xiaoting Lu,1 Jing Song,1 Linping Wang,1 Huan Li,1 Fangqu Liu,1 Yidan Zhang,1 and Qiao Niu1,2,3
Affiliations:
1 Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China;
2 Key Lab of Environmental Hazard and Health of Shanxi Province, Shanxi Medical University, Taiyuan, Shanxi 030001, China;
3 Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, Taiyuan, Shanxi 030001, China;
4 Department of Anatomy, Shanxi Medical University, Taiyuan, Shanxi 030001, China
Abstract:
Aluminum is a known neurotoxin that can induce Aβ deposition and abnormal phosphorylation of tau protein, leading to Alzheimer disease (AD)-like damages such as neuronal damage and decreased learning and memory functions. In this study, we constructed a rat model of subchronic aluminum maltol exposure, and the whole-transcriptome sequencing was performed on the hippocampus of the control group and the middle-dose group. A total of 167 miRNAs, 37 lncRNAs, 256 mRNAs, and 64 circRNAs expression changed. The Kyoto Encyclopedia of Genes and Genomes showed that PI3K/AKT pathway was the most enriched pathway of DEGs, and IRS1 was the core molecule in the PPI network. circRNA/lncRNA-miRNA-mRNA networks of all DEGs, DEGs in the PI3K/AKT pathway, and IRS1 were constructed by Cytoscape. Molecular experiment results showed that aluminum inhibited the IRS1/PI3K/AKT pathway and increased the content of Aβ and tau. In addition, we also constructed an AAV intervention rat model, proving that inhibition of miR-96-5p expression might resist aluminum-induced injury by upregulating expression of IRS1. In general, these results suggest that the ceRNA networks are involved in the neurotoxic process of aluminum, providing a new strategy for studying the toxicity mechanism of aluminum and finding biological targets for the prevention and treatment of AD.
References:
https://www.pubpeer.com/publications/74B0351D283543D4F8B77C91DCE507
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