神奇的免疫疗法，背后竟有这么多故事……

从发现到临床应用：带你走近国内首个PD-L1抑制剂。

参考资料

[1] Graham EA, Singer JJ. Successful removal of an entire lung for carcinoma of the bronchus[J].JAMA, 1933, 101(18):1371-1374

[2] LM Schwartz et al. Programmed cell death, apoptosis and killer genes. Immunol Today 14 (12), 582-90. Dec 1993.

[3] Yasumasa Ishida, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. The EMBO Journal vol. 1 1 no. 1 1 pp.3887 - 3895, 1992

[4] Taku Okazaki  and Tasuku Honjo，PD-1 and PD-1 ligands: from discovery to clinical application，The Japanese Society for Immunology. Int Immunol , 19 (7), 813-24.

[5] https://www.sciencedirect.com/topics/medicine-and-dentistry/durvalumab

来源：“医学界”微信公众号