西南医学中心Xin Liu实验室招聘博士后研究员
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西南医学中心Xin Liu实验室
Postdoctoral Fellow Position at UT Southwestern Medical Center
on ‘Chromatin Structure and Genome Regulation’
中文版简介
位于UT Southwestern Medical Center， Cecil H. and Ida Green Center for Reproductive Biology Sciences的Xin Liu实验室提供博士后研究员职位，研究染色质结构和基因组调控。
基于染色质的基因组调控机制是生物学中长期存在的谜团。Liu验室的研究重点是大型染色质复合物的结构和功能。他们决定了可遗传的染色质结构的形成并对基因组功能产生重大影响。这些染色质复合物在诸如癌症和发育障碍的人类疾病中也经常失调。为实现研究目标，Liu实验室使用结构生物学工具，包括生化重组（例如蛋白质–蛋白质、蛋白质–核小体、或蛋白质–非编码RNA复合物）、X射线晶体学和冷冻电镜，揭示染色质复合物的三维结构。此外，在正在进行的项目中，Liu实验室通过使用基因组编辑和基因组学工具对癌症和干细胞进行基于结构的功能研究。实验室近期发表的文章包括：Science 350:aac4383 (2015) (PMID: 26472914), eLife 6:e31558 (2017) (PMID: 29185984), Molecular Cell 69:840-852 (2018) (PMID: 29499137), PNAS 117:16992-17002 (2020) (PMID: 32631994), Molecular Cell 77:1265-1278 (2020) (PMID: 31959557)。
更多信息可以在这里找到：https://profiles.utsouthwestern.edu/profile/127166/xin-liu.html
欢迎在结构生物学、生物化学、染色质生物学或基因组学方面具有专业知识的研究人员申请。申请人须持有Ph.D.或M.D.学位和具有作为第一作者发表的研究论文。有兴趣的个人请提供简历和 2-3 个推荐人名单，点击【阅读原文】以附件发送。
Xin Liu, Ph.D.
Associate Professor
W.W. Caruth, Jr. Scholar in Biomedical Research
Cecil H. and Ida Green Center for
Reproductive Biology Sciences
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8511
Phone: 214-648-2493
Fax: 214-648-0383
https://profiles.utsouthwestern.edu/profile/127166/xin-liu.html
关于我们的博士后培训计划和福利的信息可以在我们的博士后手册中找到: Postdoc Handbook 或者 http://www.utsouthwestern.edu/postdocs.
英文版简介
Postdoctoral fellow position is available in the laboratory of Xin Liu, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study chromatin structure and genome regulation.
The basis of genome regulation by chromatin is a long-standing mystery in biology. Research in the Liu Lab is focused on structure and function of large chromatin complexes, which dictate formation of heritable chromatin structure and impact genome function. These chromatin complexes are also frequently dysregulated in human disease, including cancers and developmental disorders. To achieve the research goal, the Liu Lab uses structural biology tools, including biochemical reconstitution (e.g. protein-protein, protein-nucleosome, or protein-non-coding RNA complexes), X-ray crystallography and cryo-EM, to reveal three-dimensional structures of chromatin complexes. In addition, in the ongoing projects the Liu Lab performs structure-based functional studies in cancer and stem cells by employing genome editing and genomics tools. Examples of recent publications from the lab include: Science 350:aac4383 (2015) (PMID: 26472914), eLife 6:e31558 (2017) (PMID: 29185984), Molecular Cell 69:840-852 (2018) (PMID: 29499137), PNAS 117:16992-17002 (2020) (PMID: 32631994), Molecular Cell 77:1265-1278 (2020) (PMID: 31959557).
More information can be found here: https://profiles.utsouthwestern.edu/profile/127166/xin-liu.html.
Applicants with demonstrated expertise in structural biology, biochemistry, chromatin biology, or genomics are encouraged to apply. Applicants must hold a Ph.D. and/or M.D. degree with first author publications. Interested individuals should provide a CV and a list of 2-3 references.
Xin Liu, Ph.D.
Associate Professor
W.W. Caruth, Jr. Scholar in Biomedical Research
Cecil H. and Ida Green Center for
Reproductive Biology Sciences
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8511
Phone: 214-648-2493
Fax: 214-648-0383
https://profiles.utsouthwestern.edu/profile/127166/xin-liu.html
Information on our postdoctoral training program and benefits can be found in our Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.