RNA甲基化研究必看的10篇经典综述与高分文章
关于大热点RNA甲基化修饰,我们去年介绍过,大家可以温习一下:
2018年国自然基金结果出来后,下面是我们不完全统计的15项医学部基金结果:
9个面上项目,6个青年项目。从研究方向上来看,肿瘤居多,占了12项。可见RNA甲基化这个热点已经在肿瘤这个领域悄悄兴起,所谓“春江水暖鸭先知”,热不热,看肿瘤领域的情况就知道了。
下面就来梳理一下RNA甲基化研究必看的经典综述和10分以上的文章。
1. (Review) m6A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression.Trends Genet. 2017 Jun;33(6):380-390.
2. (Review) RNA editing-dependent epitranscriptome diversity in cancer stem cells.Nat Rev Cancer. 2017 Jun;17(6):381-392.
3. (Review) Messenger RNA modifications: Form, distribution, and function.Science. 2016 Jun 17;352(6292):1408-12.
4. (Research Article) m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.Cancer Cell. 2017 Apr 10;31(4):591-606.e6.
5. (Research Article) The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.Nat Med. 2017 Sep 18.
6. (Research Article) The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence.Mol Cell. 2017 Sep 21;67(6):1059-1067.e4.
7. (Research Article) m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.Nature. 2017 Aug 17;548(7667):338-342.
8. (Research Article) The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.Cell. 2017 May 18;169(5):824-835.e14.
9. (Research Article) FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.Cancer Cell. 2017 Jan 9;31(1):127-141.
10. (Research Article) METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6-methyladenosine-dependent primary MicroRNA processing. Hepatology. 2017 Feb;65(2):529-543.
这篇文章我们介绍过,大家可以看解读:二军大孙树汉教授Hepatology发表最新成果。
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