【直播】【中科院化学研究所】高分子科学前沿讲座

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高分子科学前沿讲座

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报告一：Smart Textiles for Personalized Health Care

时间：2022年6月20日  9:00-10:00

陈俊 教授

加州大学洛杉矶分校

报告二：Sphingomyelin-derived Cancer Nanotherapeutics

时间：2022年6月20日 10:00-11:00

卢剑琴 助理教授

The University of Arizona R. Ken Coit College of Pharmacy

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中国科学院化学研究所

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报告题目：Smart Textiles for Personalized Health Care

Jun Chen, Ph.D
个人简历：陈俊现任加州大学洛杉矶分校生物工程系助理教授，并创建了可穿戴生物电子实验室，致力于以纳米技术和生物电子为基础，以智能织物、可穿戴器件和人体局域网为形式的，在能源、传感、环境和医疗领域内的前沿应用研究。已经出版书籍2册，论文220多篇，其中以通信作者在Chem. Rev. (2), Chem. Soc. Rev. (2), Nat. Mater., Nat. Electron. (3), Nat. Commun. (2), Sci. Adv., Joule (3)，Matter (6)，Adv. Mater. (8) 等刊物发表论文120余篇。他目前的H指数为81，连续2019，2020, 2021年入选Web of Science 全球高被引学者。
报告摘要：Health care should move from its current reactive and disease-centric system to a personalized, predictive, preventative, and participatory model with a focus on disease prevention and health promotion. As the world marches into the era of the Internet of Things (IoT) and 5G wireless, technology renovation enables the industry to offer a more individually tailored approach to healthcare with better health outcomes, higher quality, and lower cost. However, empowering the utility of IoT-enabled technologies for personalized health care is still significantly challenged by the shortage of cost-effective on-body biomedical devices to continuously provide real-time, patient-generated health data. Merging biomedical devices and textiles becomes increasingly important owing to their incomparable wearing comfort and the growing trend of IoT. In this talk, I will introduce our current research on smart textiles for biomonitoring, therapy, and textile power generation as an energy solution for future on-body biomedical devices.

报告题目：Sphingomyelin-derived Cancer Nanotherapeutics

Jianqin Lu, Ph.D个人简历：Jianqin Lu (卢剑琴) is an Assistant Professor and Director of Pharmaceutics and Pharmacokinetics Track at The University of Arizona R. Ken Coit College of Pharmacy. The Lu lab strives to develop innovative, safe, and efficacious therapeutics at the interface of drug delivery, synthetic chemistry, pharmaceutics, nanotechnology, and tumor immunology to address the pressing unmet needs in cancer therapy and prevention. His research work has been published in Nature Nanotechnology, Nature Communications, Journal of Hepatology, ACS Nano, Biomaterials, Small, etc. Dr. Lu received the Norman R. and Priscilla A. Farnsworth Award at the University of Pittsburgh, the USHHS Ruth L. Kirschstein Institutional National Research Service Award in Tumor Immunology, and the PhRMA Foundation Research Starter Grant in Drug Delivery, among others. Dr. Lu serves as the Secretary of Knowledge Management in Pharmaceutics Section of the American Association of Colleges of Pharmacy.
报告摘要：Despite the enormous therapeutic potential of immune checkpoint blockade (ICB), it benefits only a small subset of patients. Some chemotherapeutics can switch ‘immune-cold’ tumors to ‘immune-hot’ to synergize with ICB. However, safe and universal therapeutic platforms implementing such immune effects remain scarce. In this talk, I will introduce the sphingomyelin-derived camptothecin nanotherapeutic platform (camptothesome) recently developed in my lab. Camptothesome can elicit potent cytotoxic T lymphocyte responses, potentiating PD-L1/PD-1 co-blockade to eradicate MC38 colorectal adenocarcinoma with developed memory immunity; and improve pharmacokinetics, diminish systemic toxicities, penetrate deeply into tumor and outperform the therapeutic efficacy of Onivyde. Camptothesome can co-load IDO1 inhibitor indoximod into its interior using the lipid-bilayer-crossing capability of doxorubicin, eliminating advanced orthotopic CT26-Luc tumors and late-stage B16-F10-Luc2 melanoma with complete metastasis remission when combined with ICB and folate targeting. The sphingomyelin-based nanoplatform and doxorubicin-enabled transmembrane transporting technology are generalizable to various therapeutic agents, paving the way for transformation of the cancer immunochemotherapy paradigm.

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