hLife创刊号正式出版

Volume 1, Issue 1

    封 面 解 读

Illustrated by George F. Gao

The major stages of medical development are presented from far to near. Elements of basic medical research and related clinical applications are involved in the rotating time-space tunnel composed of green plants, reflecting the development and integration of basic research and clinical applications. Each time when we use a research discovery to strengthen medicine, our weapons are leveled up to better protect the dignity of life. There are also human, animal and environmental elements in the time tunnel, reflecting that animal health, human health and environmental health are mutually linked and interdependent, illustrating the concept of One Health. As we know, the animals are the original or intermediate hosts of many human infectious diseases, and environmental change has a major impact on human health. In front of science, we are all children full of curiosity. By applying innovative scientific advances to clinical applications, we could live in harmony and see a healthier and happier future.

目     录

导     读

1. Editorial: hLife: Linking Basic Research and Clinical Applications

通讯作者：高福、董晨、Jules A. Hoffmann

hLife主编回顾了人类健康科学的发展历程，指出人类目前所面临的挑战，以及未来健康科学的发展态势。作为健康科学领域的综合性高起点英文期刊，hLife秉承聚焦健康科学领域前沿、促进基础研究与临床应用融合发展的办刊理念，由三位主编领衔，60余位全球健康科学领域的卓越科学家携手，致力于将hLife打造成为健康科学领域的权威学术交流平台。hLife于2022年成功入选“中国科技期刊卓越行动计划高起点新刊”。

引用：

Gao GF, Dong C, Hoffmann JA. hLife: Linking basic research and clinical applications. hLife 2023;1:1–2.

DOI：

https://doi.org/10.1016/j.hlife.2023.10.005

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2. Dialogue: The discovery of T–B cell lineages: An interview with Professor Max D. Cooper

通讯作者：董晨、Max D. Cooper

2019年9月, 生物医学领域的重要奖项拉斯克基础医学奖（Albert Lasker Basic Medical Research Award）授予来自美国埃默里大学医学院的Max D. Cooper教授，以表彰他为发现B淋巴细胞所做出的重要贡献。该奖项被誉为诺贝尔生理学与医学奖的“风向标”。

引用：

Dong C, Cooper MD. The discovery of T–B cell lineages: An interview with Professor Max D. Cooper. hLife 2023;1:3–7.

DOI：

https://doi.org/10.1016/j.hlife.2023.03.001 

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3. Perspective：Fecal microbiota transplantation: A new strategy to delay aging

通讯作者：刘光慧、任捷

本研究系统总结了粪菌移植在衰老研究中的最新进展：与老年人或患病个体相比，年轻个体的肠道微生物群对宿主有益；当寿命较长物种的肠道微生物群移植到寿命较短的物种中时，也会对宿主产生有益影响。

引用：

Yan H, Ren J, Liu GH. Fecal microbiota transplantation: A new strategy to delay aging. hLife 2023;1:8–11.

DOI：

https://doi.org/10.1016/j.hlife.2023.06.002

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4. Article: A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein

通讯作者：高福、邬征、谢正德

引用：

Dai L, Song J, Xu L, et al. A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein. hLife 2023;1:12–25.

DOI：

https://doi.org/10.1016/j.hlife.2023.09.003

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5. Article: Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals

通讯作者：王林发、Tan Chee Wah

引用：

Tan CW, Zhu F, Chia WN, et al. Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals. hLife 2023;1:26–34. 

DOI：

https://doi.org/10.1016/j.hlife.2023.07.002

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6. Article: Mouse model for pangolin-origin GX/P2V/2017 coronavirus infection and cross-protection of COVID-19 ZF2001 subunit vaccine

通讯作者：高福、王奇慧、曹务春、高玉伟

本研究探讨了鼠作为庭院动物传播穿山甲来源冠状病毒的可能性，以及基于冠状病毒刺突蛋白受体结合域（RBD）设计的疫苗作为广谱冠状病毒疫苗的潜质。

引用：

Qu X, Jia Y, Jia N, et al. Mouse model for pangolin-origin coronavirus GX/P2V/2017 infection and cross-protection from COVID-19 ZF2001 subunit vaccine. hLife 2023;1:35–43.

DOI：

https://doi.org/10.1016/j.hlife.2023.07.001

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7.Article: Emergence of hypervirulent Pseudomonasaeruginosa pathotypically armed with co-expressed T3SS effectors ExoS and ExoU

通讯作者：冯婕、白芳

本文揭示了同时携带III型分泌系统效应蛋白ExoS和ExoU的铜绿假单胞菌（exoS+/exoU+）的毒力特征和遗传演化机制。

引用：

Song Y, Mu Y, Wong NK, et al. Emergence of hypervirulent seudomonas aeruginosa pathotypically armed with co-expressed T3SS effectors ExoS and ExoU. hLife 2023;1:44–56.

DOI：

https://doi.org/10.1016/j.hlife.2023.02.001

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8. Letter: T cell cross-reactivity in Autoimmune-like Hepatitis triggered by COVID-19

通讯作者：王健伟、李贵登

引用：

Liu Y, Wang Y, Peng Z, et al. T cell cross-reactivity in autoimmune-like hepatitis triggered by COVID-19. hLife 2023;1:57–61.

DOI：

https://doi.org/10.1016/j.hlife.2023.09.002

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往期推荐

期刊简介

hLife是中国科学院微生物研究所主办，中国生物工程学会和上海市免疫治疗创新研究院联合支持，与国际出版商爱思唯尔合作的健康科学领域综合性英文期刊。

hLife聚焦健康科学领域的前沿进展，旨在促进基础研究与临床应用的融合发展。期刊发表与医学相关各研究领域最新成果，学科领域包括（但不限于）病原生物学、流行病学、生理学、免疫学、结构生物学、疾病监测、肿瘤、药物、疫苗和健康政策等。

2022年成功入选“中国科技期刊卓越行动计划高起点新刊”。

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