hLife 2023年第二期正式出版

Volume 1  Issue 2

    封 面 解 读

饶毅

戴熙慧敏

For more than 100 years, the fruit fly (Drosophila melanogaster) which is the model organism has contributed to the research of genetics, development, and behavior, revealing fundamental principles, molecular mechanisms, and neural circuits that shed light on human health and diseases. The clock surrounding the fruit fly indicates circadian and sleep behavior. There are a lot of dishes in front of the fly, sybolizing the feeding behavior of a fly. Like us, flies also eat and sleep around the clock, which is regulated by circadian and other environmental inputs. Additionally, the molecule in the picture is guanosine tetraphosphate (ppGpp), the “magic spot” nucleotides originally known as involved in the stringent response in bacteria when there is an amino acid shortage. In the cover study in this issue, ppGpp was found to be the key molecule regulating sleep duration, sleep latency, and starvation-induced sleep loss, building a bridge between feeding and sleep.

目     录

导     读

1. Dialogue: Global public health crisis response: A roundtable discussion with Professor George Fu Gao, Professor Jules A Hoffmann, Professor Chris Walzer and Professor Jiahai Lu

通讯作者：高福、Jules A. Hoffmann、Chris Walzer、陆家海

引用：

Gao GF, Hoffmann JA, Walzer C, et al. Global public health crisis response: A roundtable discussion with Professor George Fu Gao, Professor Jules A Hoffmann, Professor Chris Walzer and Professor Jiahai Lu. hLife 2023;2:63–70. doi: https://doi.org/10.1016/j.hlife.2023.10.001

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2. Review: Mucosal immune responses in the lung during respiratory infection: The organization and regulation of iBALT structure

通讯作者：王硕、刘翠华

Highlights

• Inducible bronchus-associated lymphoid tissue (iBALT) plays a crucial role in controlling lung infections

• iBALT organization is supported by stromal cell activation and immune cell recruitment in response to antigen stimulation

• The iBALT structure carries out regulatory functions during respiratory virus or Mycobacterium tuberculosis (Mtb) infections

• iBALT is a critical lymphoid organ in the lung, capable of storing memory lymphocytes, and can be induced by vaccination

引用：

Gao X, Liu C, Wang S. Mucosal immune responses in the lung during respiratory infection: The organization and regulation of iBALT structure. hLife 2023;2:71–82. doi: https://doi.org/10.1016/j.hlife.2023.09.001

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3. Review：SARS-CoV-2: Possible role in children with acute hepatitis of unknown origin

通讯作者：张拥军, 陈爱玲

引用：

Yu R, Chen A, Zhang Y. SARS-CoV-2: Possible role in children with acute hepatitis of unknown origin. hLife 2023;2:83–92. doi: https://doi.org/10.1016/j.hlife.2023.10.008

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4. Perspective: A roadmap for exploring the untouched protein space for biology and medicine

通讯作者：王军

除了我们已知的蛋白质外，还存在大量理论上存在且有潜在功能的蛋白质，本文对如何研究这些蛋白质提出了展望。

引用：

Wang J. A roadmap for exploring the untouched protein space for biology and medicine. hLife 2023;2:93–97. doi: https://doi.org/10.1016/j.hlife.2023.06.001

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5. Article: ppGpp is present in, and functions to regulate sleep of, Drosophila

通讯作者：饶毅

四磷酸鸟苷（ppGpp）也被称为魔点核苷 (“magic spot” nucleotide)，其参与调节细菌对饥饿的应激反应。本研究通过多种实验证据表明其在果蝇中也存在，并且发挥睡眠调节的功能，特别是参与饥饿对睡眠的调节。

引用：

Dai X, Yang W, Zhang X, et al. ppGpp is present in, and functions to regulate sleep of, Drosophila. hLife 2023;2:98–114. doi: https://doi.org/10.1016/j.hlife.2023.10.004

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6. Article: Structural plasticity of human leptin binding to its receptor LepR

通讯作者：高福、卢德芬

Highlights

•Cryo-electron microscopy structures of human leptin–leptin receptor (LepR) complex

•The human leptin–LepR complex could adopt different conformations

•Conformational rearrangement of leptin upon binding with LepR

•Mechanism of human leptin-mediated LepR signaling

引用：

Xie Y, Li X, Qi J, et al. Structural plasticity of human leptin binding to its receptor LepR. hLife 2023;2:115–123. doi: https://doi.org/10.1016/j.hlife.2023.10.010

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7.Article: Structural basis of Semliki Forest virus entry using the very-low-density lipoprotein

通讯作者：宋豪

Highlights

•Semliki Forest virus (SFV) binds very-low-density lipoprotein receptor (VLDLR) using E1-DIII non-canyon region

•Multiple LDLR class A (LA) repeats in VLDLR enhance binding affinity to SFV

•VLDLRs from different species employ distinct LA repeats for SFV binding

引用：

Li Y, Zhao Z, Liu S, et al. Structural basis of Semliki Forest virus entry using the very-low-density lipoprotein receptor. hLife 2023;2:124–136. doi: https://doi.org/10.1016/j.hlife.2023.11.001

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