hLife 2024年第四期正式出版

Volume 2  Issue 4

封面解读

王显花

杨茂君

The mitochondrion undergoes mitoflashes, shown as flaming peaks for heat production. As the powerhouse of the cell, mitochondria produce ATP, the energy currency of life, through respiratory chain complexes that can form a megacomplex (shown in the bubble), whose structure is being resolved by Zhang and his colleagues. According to the conformational change of megacomplex, it is concluded that respiratory chain complex I, complex III, and complex IV work in a synergistical manner, in which the activation state of complex I can influence the Rieske domain movement of complex III and the swing range of complex IV. Mitochondria also generate elementary electrochemical excitations in the form of mitoflashes, which represent transient uncoupling of mitochondrial respiration. Chen and her colleagues show a close link between mitoflashes and heat production. They find that when the body is challenged with environmental cold, mitoflashes are extensively activated in brown adipocytes, a specialised cell type for adaptive thermogenesis. As stimulation of brown adipocyte thermogenesis increases systematic energy expenditure, understanding mitoflash signalling in heat production will open up avenues to combat obesity and its associated metabolic disorders.

目     录

导     读

1.Innovating medicine: The path forward

通讯作者：董晨

引用：

Dong C. Innovating medicine: The path forward. hLife 2024;2:147.

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2.Medical journals: The past, present, and future

通讯作者：董晨，Eric Rubin, 肖瑞平

2023年11月15日，我们有幸邀请到《新英格兰医学杂志》（The New England Journal of Medicine, NEJM）的主编Eric Rubin教授和副主编肖瑞平教授一同出席见证hLife的创刊。创刊仪式结束后，hLife主编董晨院士与Eric Rubin教授和肖瑞平教授就医学期刊为话题展开了对话。他们探讨了医学期刊的发展历程、社会所面临的医学挑战，以及期刊如何随着时间的推移演化以适应和推动医学的发展。

引用：

Dong C, Rubin E, Xiao RP. Medical journals: The past, present, and future. hLife 2024;2:148–153.

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3.Aldo-keto reductase 1B: Much learned, muchmore to do

通讯作者：潘磊

Highlights

•Aldo-keto reductase 1B is deeply involved in metabolic reprogramming, not least in glucose metabolism.

•Aldo-keto reductase 1B's ability to control the metabolism of immune cells can influence the course of inflammation.

•Aldo-keto reductase 1B is associated with cancer development and drug resistance.

•Clinical applications urgently require the development of specific and safe aldo-keto reductase 1B inhibitors.

引用：

Zhao Y, Zhang M, Li H, et al. Aldo-keto reductase 1B: Much learned, much more to do. hLife 2024;2:154–178.

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4.Mitochondrial flashes are interlinked with adaptive thermogenesis in brown adipocytes

通讯作者：王显花

本文发现棕色脂肪细胞中的量子化线粒体信号事件—线粒体炫（mitochondrial flash）能够响应产热刺激，在适应性产热过程中发挥重要作用。

引用：

Chen X, Bahetiyaer H, Song X, et al. Mitochondrial flashes are interlinked with adaptive thermogenesis in brown adipocytes. hLife 2024;2:179–188.

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5.Structural basis for the regulatory mechanism ofmammalian mitochondrial respiratory chainmegacomplex-I₂III₂IV₂

通讯作者：杨茂君、谷金科

线粒体呼吸链超级复合物I₂III₂IV₂（MCI₂III₂IV₂）中，复合物I、III和IV之间是通过特殊的蛋白亚基相互协调来发挥功能的，且MCI₂III₂IV₂可处于有催化活性和无催化活性两种构象，这两种构象之间可以通过中间构象互相转换。

引用：

Zhang L, Guo R, Xiao C, et al. Structural basis for the regulatory mechanism of mammalian mitochondrial respiratory chainmegacomplex-I₂III₂IV₂. hLife 2024;2:189–200.

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6.Optimized pretreatment increases thesusceptibility of hepatitis B virus infectionby enhancing actomyosin-driven cellspreading

通讯作者：酒亚明

引用：

Cui S, Gao W, Li Z, et al. Optimized pretreatment increases the susceptibility of hepatitis B virus infection by enhancing actomyosin-driven cell spreading. hLife 2024;2:201–205.

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