表观遗传调控盛宴·细胞生物学学会2017年会 | 提前了解报告人 | 招募小记者

2017年9月26-29日，中国细胞生物学学会2017年全国学术大会在厦门国际会展中心举行，会议主题：探索细胞 创新未来。

明天下午，28日13:30-18:00，4楼观海厅，分会场6，一场细胞命运的表观遗传调控的盛宴即将拉开帷幕。

参会前要做哪些准备？三个要点：

1. 会前了解报告人和报告题目；见本文后半部分小丫整理的报告题目和报告人研究兴趣，参考参会准备 | 预习报告人的研究兴趣；

2. 会上听思路和八卦，记笔记，建立Network，参考在学术会议上建立有效的Network；

3. 会后整理、总结。招募小记者总结参会体验，文末有报名方法。

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细胞命运的表观遗传调控分会场

28日13:30-18:00，4楼观海厅，分会场6

小丫把报告人报告题目和实验室主页上的研究兴趣、近年发表的paper集中到这里，按报告顺序排列，以便速查。注：仅列出主页上最新一年的文章，多数更新到2017、2016、2015年；有两位报告人主页最新文章是2015年以前的，小丫就自己搜了一下。

13:30-13:50    刘峰 中国科学院动物研究所
Title: m6A modulates haematopoietic stem and progenitor cell specification

1. Genetic control of hematopoietic stem cell development.

We are studying molecular mechanisms of HSC emergence and maintenance including the key signal transduction pathways, gene regulatory network (GRN) and epigenetic modification, in order to better understand programming/reprogramming of these cells for potential therapeutic application. Our studies showed that may factors or signaling pathways play important role in HSC development, such as G protein-coupled receptor, inflammatory signaling, ERK signaling, Ncor2, Fev and miR142-3p. Meanwhile, Blood flow is essential for the maintenance of HSC programming through KLF2-NO signaling cascade.

2. Molecular regulation of T cell specification and erythroid maturation.

We are also interested in HSC differentiation. Recently, we found that Irf4 regulates the choice between T lymphoid-primed progenitor and myeloid lineage fates during embryogenesis. We also reported that Foxn1 plays an essential role during thymopoiesis in zebrafish to maintain TEC and T cell development through direct regulation of mcm2. In addition, two Klf family genes are demonstrated to be important for erythroid maturation in zebrafish.

To obtain functional HSCs in vitro is a major goal of basic research in hematopoiesis and holds great promise in regenerative medicine. However, production of transplantable HSCs in vitro has not yet been achieved. The bottleneck for this is that the molecular regulation of HSC development (emergence, maintenance and differentiation) in vivo is still poorly understood. Our ongoing and future work focuses on molecular mechanisms underlying HSC development in vivo and how to make functional HSCs in vitro. The research findings in our lab will expand our understanding on the gene regulatory network of HSC development in vertebrates, and will provide new insights into the in vitro generation of transplantable HSCs for potential clinical applications.

1. Epigenetic regulation of left-right asymmetry by DNA methylation. EMBO J. 2017 Sep 7. pii: e201796580. doi: 10.15252/embj.201796580.

2. m6A modulates haematopoietic stem and progenitor cell specification. Nature. 2017 Sep 6. doi: 10.1038/nature23883

3. The vascular niche regulates hematopoietic stem and progenitor cell lodgment and expansion via klf6a-ccl25b. Dev Cell. 42(4):349-362(2017)

4. Application of aorta-gonad-mesonephros explant culture system in developmental hematopoiesis. JoVE (2017)

5. The role of serotonin beyond the central nervous system during embryogenesis. Front Cell Neurosci. 11:74 (2017)

6. BLOS2 maintains hematopoietic stem cells in the fetal liver via repressing Notch signaling. Exp Hematol. 51:1-6.e2 (2017)

7. 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 214(2):529-545(2017)

8. Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin. Leukemia. 31(5):1079-1086(2017)

13:50-14:10    高绍荣 同济大学
Title: Epigenetic regulation in early embryo development and somatic cell reprogramming    

主要从事早期胚胎发育、体细胞重编程与干细胞的分子机制与转化研究。目前主要研究方向包括：

1．早期胚胎发育尤其是细胞全能性建立与第一次细胞命运决定的表观遗传调控机制；

2．利用体细胞核移植与诱导多能干细胞技术研究体细胞重编程的分子机制；

3. 利用病人诱导多能干细胞进行疾病发生机制及干细胞转化医学研究。

1. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos. Nature 537(7621):558-562.(2016)

2. Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming. Cell Reports 14(6):1540-54.(2016)
   

3. LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 7:10481. (Co-correspondence)(2016)
   

4. Naïve Induced Pluripotent Stem Cells Generated From β-Thalassemia Fibroblasts Allow Efficient Gene Correction With CRISPR/Cas9. Stem Cells Transl Med. 5(1):8-19.(2016)

14:10-14:30    翁杰敏 华东师范大学

Title: DNA甲基化稳态遗传的正负调控

学校网站上个人介绍的最新文章是2012年的，多年未更新。

搜到最新发表的一篇文章：

Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin. Proceedings of the National Academy of Sciences 114.31 (2017): 8229-8234.

14:30-14:45    孙英丽 中国科学院北京基因组研究所
Title: Identification of LSD1 as a Therapeutic Target of Triple Negative Breast Cancer    

癌症基因组和表观基因组研究

肿瘤细胞中表观遗传调控和DNA损伤修复通路的关系的研究

针对肿瘤干细胞及肿瘤细胞特异表观修饰靶点的药物设计和筛选

针对肿瘤细胞DNA损伤修复通路的药物设计和筛选

干细胞与肿瘤干细胞的基因组稳定性及表观基因组的研究

1. Circulating Tumor DNA as Biomarkers for Cancer Detection, Genomics, Proteomics & Bioinformatics, 2017, 15(2): 59-72 

2. The application of liquid biopsy in precision medicine: opportunities and challenges, Frontiers of Medicine. 2017, doi: 10.1007/s11684-017-0526-7

3. DNA methylation signatures in circulating cell-free DNA as biomarkers for the early detection of cancer. Sci China Life Sci. 2017 Apr; 60(4):356-362. 

4. Cell proliferation downregulated by TGF-β2-triggered G1/S checkpoint in clinical CAFs. Cell cycle. 2017, Jan 17; 16(2):172-178. 

14:45-15:00    曹萤 南京大学模式动物研究所
Title: Epigenetically regulated cancer cell terminal differentiation discloses the nature of tumorigenesis  

以非洲爪蛙（Xenopus laevis）为模式动物研究早期胚胎细胞向不同胚层分化的分子调控机理；肿瘤细胞的分化和调控。

1. Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning. Dev Dyn. 2015 Oct;244(10):1328-46. (*Correspondence).

2. The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling. J Biol Chem. 2015 Sep 4;290(36):21925-38.

3. JmjC Domain-containing Protein 6 (Jmjd6) Derepresses the Transcriptional Repressor Transcription Factor 7-like 1 (Tcf7l1) and Is Required for Body Axis Patterning during Xenopus Embryogenesis. J Biol Chem. 2015 Aug 14;290(33):20273-83. (*Correspondence).

4. Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin. Dev Cell. 2015 Jun 22;33(6):660-74. (*Correspondence).

5. Germ layer formation during Xenopus embryogenesis: the balance between pluripotency and differentiation (Review). Sci China Life Sci. 2015 Apr;58(4):336-42. (*Correspondence).

16:30-16:50    金颖 中国科学院上海生命科学研究院（人口健康领域）
Title: Jmjd1c Ensures Mouse Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming through Controlling MicroRNA Expression    

1、多能细胞自我更新及发育全能性的分子机制
2、多能干细胞向神经谱系分化的分子调控

1. Comprehensive profiling reveals mechanisms of SOX2-mediated cell fate specification in human ESCs and NPCs. Cell Res. 26(2):171-189.(2016) 

2. Calcineurin-NFAT Signaling Controls Somatic Cell Reprogramming in a Stage-Dependent Manner. J Cell Physiol. 231(5):1151-62.(2016) 

3. Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration. Stem Cell Research & Therapy. 2015 Nov 9;6:219.(2015) 

4. Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteins. J Cell Sci. 2015 Aug 1;128(15):2881-90.(2015) 

16:50-17:10    王纲 中国科学院上海生物化学与细胞生物学研究所
Title：Mediator Complex: epigenetic regulation and cell fate control    

哺乳动物的转录中介体（Mediator）是由大约30个蛋白质组成的多蛋白复合体，是介于转录因子与mRNA Polymerase II基础转录机器之间的连接桥梁。几乎所有的基因表达都需要Mediator的调节。不同的转录因子受到环境及发育信号的影响时，就会与Mediator中的某个特定的亚基发生相互作用，促进Polymerase II及通用转录因子（GTFs）在特定基因起始序列上的聚集，并形成预起始复合物(PIC)，从而控制基因表达的水平。

长期专注于转录中介体在发育和疾病中的功能研究。首次提出平滑肌与脂肪细胞的“双向调控”及其共同起源（Dev Cell, 2009; Genes Dev, 2012）；发现Mediator不同亚基在胚胎干细胞干性维持及多谱系细胞分化中的不同功能（Development, 2015）；发现转录中介体亚基MED23参与调控间充质干细胞向成骨细胞分化过程，并影响成骨的发育（Nat Commun, 2016）；揭示Mediator作为表观遗传调控因子,调控癌症与肌肉细胞分化之间的拮抗作用（EMBO J, 2015）；多次获邀撰写Mediator通过转录、表观遗传调控决定细胞谱系发育的综述（Development, 2014; WIREs RNA, 2015）；多项工作作为Mol Cell，EMBO J等重要学术期刊的封面文章发表，获同期专评，以及Faculty1000、NatureAsia-AIMBN的亮点评论。

1. Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nat Commun. 2016; 7:11149.

2. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J. 2015, 34(23):2885-902. (Cover story with commentary)

3. Mediator Med23-deficiency Enhances Neural Differentiation of Embryonic Stem Cells through Modulating BMP Signaling. Development. 2015; 142(3):465-76.

4. ‘Mediator-ing’ messenger RNA processing. WIREs RNA. 2015; 6(2):257-269. (Invited review)

17:10-17:30    颉伟 清华大学
Title: Reprogramming of chromatin architecure in early mammalian development    

研究兴趣包括表观遗传学，基因组学和发育生物学。同时利用分子生物学、发育生物学和计算生物学的方法，采用干湿实验结合的方式，研究干细胞分化和个体发育以及人类疾病中的表观遗传调控机制。本实验室将致力于：（1）动物胚胎早期发育过程中的表观遗传调控；（2）干细胞分化过程中的表观遗传调控；（3）调控序列如启动子、增强子、绝缘子以及三维基因组在发育和细胞命运决定过程中的功能；（4）表观遗传相关人类疾病的调控机理。

1. Allelic reprogramming of 3D chromatin architecture during early mammalian development. Nature 547 (232-235). (2017) 

2.  3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis. Cell 170 (357-381).(2017)

3. Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genetics 12(12): e1006474.(2016) 

4.  Isoform switch of TET1 regulates demethylation and mouse development. Molecular Cell 64 (1-12).(2016)

5. Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nature Chemical Biology 12, (1111–1118).(2016) 

6. Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature 537 (553-557).(2016). 

7. Resetting epigenetic memory by reprogramming of histone modifications in mammals. Molecular Cell 63 (1066-1079). (2016). 

8. The landscape of accessible chromatin in mammalian preimplantation embryos. Nature 534 (652-657). (2016). 

17:30-17:45    彭克松 厦门大学生命科学学院
Title: Histone demethlyase JMJD1A promotes colorectal cancer cell proliferation and invasion via enhancement of Wnt/β-catenin signaling    

彭克松是在读博士研究生，导师俞春东教授

学校网站上个人介绍的最新文章是2013年的，多年未更新。

搜到最新发表的一篇文章：

Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α.Oncogene (2017).

17:45-18:00    冯海忠 上海交通大学医学院附属仁济医院
Title: TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma    

1.  非编码RNA代谢与肿瘤干细胞

2.  组蛋白修饰与肿瘤干细胞

3.  肿瘤侵袭与转移的分子机制

4.  细胞治疗及小分子抑制剂的筛选

1. PKA-dependent phosphorylation of Dock180 at serine residue 1250 is important for PDGFR alpha-stimulated glioma growth and invasion. Neuro-Oncology. 
   

2. EGFR-phosphorylation of DCBLD2 Recruits TRAF6 and stimulates Akt-promoted Tumorigenesis. The Journal of Clinical Investigation, Septembe 2, 2014, 124(9):3741-3756. 
   

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参加细胞生物学年会，会上做笔记，茶歇建立network，会后整理思路、写参会感受，跟小伙伴儿们分享。多年后，脑子里除了厦门美食之外还能留下点儿什么 ~ ~ ~

生信大牛Shirley X. Liu是如何从会议记录中获益的？点击左下角“阅读原文”直达。

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• 稿酬300-1000元。
  

【报名方式】

• 在嘉因生物公众号里输入“CSCB+微信号”。

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曾经分享的参会感受：

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