【Live】A Series of Webinar on Nanomaterials and Applications
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Please join the webinars at the following link: koushare.com/topicIndex/i/nanomaterials-applicationsA Series of Webinar on Nanomaterials...
Speakers：Ruibing Wang、Derong CaoTime in Dallas : June 26, Saturday, 8:00-9:00 PM
Time in Beijing : June 27, Sunday, 9:00-10:00 AM
Sponsors：Nanomaterials MDPI、KouShareWelcome to A Series of Webinar on Nanomaterials and Applications
We would like to invite all the Scientific Community to participate in a Series of Webinar on Nanomaterials and Applications from April to July 2021, which is sponsored by MDPI Nanomaterials and propagated by Koushare. The Webinars were scheduled at the last weekend of each month from April to July 2021 for the convenience of audiences and the speakers. Aim and ScopeThis series of Webinars are mainly designed to offer diverse sessions that address the Theme of ‘Nanomaterials and their applications’ for the purpose of sharing new thoughts and new advances among the experts, industrialists and understudies from look into topics of Nanomaterials to share their on-going developments and applications for Better tomorrow. The scope of the webinar series is to support global research communities by empowering clusters of Professor, Scientists, Researchers, Students and Business Delegates to meet and discuss topics of Nanomaterials with frontrunners in the field. These webinars cover diverse top-ranked specialties and budding aspects of important and relatively broad subject areas including nanomaterials design and synthesis for cancer detection, drug delivery, therapeutics, sensing and safety as well as security for our better life tomorrow. The talks are aimed for public with lay languages and are open to everyone in the world!
Sincerely yours
Wei Chen, Ph.D, ProfessorDepartment of PhysicsThe University of Texas at ArlingtonArlington, Texas, USA
Special website：koushare.com/topicIndex/i/nanomaterials-application
Dr. Chen Wei
Dr. Wei Chen is a professor at the department of Physics, UT Arlington. He has been engaged in cutting-edge nanotechnology research for many years and is an internationally renowned expert in nanomedicine and cancer nanotechnology. He is well known for his inventions in cancer nano-targeted therapy and deep cancer photodynamic therapy. Currently he has published 295 papers in famous academic journals such as PNAS, Nano Letters, Signal Transduction and Targeted Therapy(Nature), Advanced Materials, Advanced Functional Materials, Materials Today Physics, presided over the compilation of 1 monograph (three volumes), and participated in the compilation of 13 monographs. His papers have been cited more than 11460 times, and his H index is 56, including one paper with 685 citations, 13 papers with more than 200 times, 28 papers with more than 100 times. He has 20 US patents granted and he has been funded with more 30 scientific research projects with a total funding of more than 9 million U.S. dollars. His early pioneering work on thermoluminescence of nanoparticles were adopted by Charles P. Poole Jr. and Frank J. Owens in their first Textbook ‘Introduction to Nanotechnology’ published in 2003. Dr. Chen's scientific research work has attracted wide attention and has been reported by the American TV program CBS. Dr. Chen received the University distinguished record of research and creative activity award in 2020. He is one of the 35 scientists from the country to be included in the National Academy of Inventors 2020 class of Senior Members. He was elected be a Fellow of the International Association of Advanced Materials (Sweden) and a Vebleo Fellow in 2020 and a Sigma Xi full member in 2021.
01
Supramolecular cell-hitchhiking delivery of drugs for targeted therapy of inflammatory diseases
Abstract
Cells are the basic unit of living organisms, and using them as drug carriers has unique advantages. For example, it can significantly improve the efficiency of targeted drug delivery. There are currently two construction strategies for cell-hitchhiking delivery systems. One is to directly phagocytose drugs (including nano-drugs) through endocytosis, and the other is to use covalent bonds or biological ligand-receptor interactions to conjugate nanomedicine to the surface of live cells. However, the cells that phagocytize the drug carrier usually degrade the drug before reaching the target. Covalent binding involves a complex synthesis process on the cell surface, which usually impairs the physiological function of the carrier cells. The ligand-receptor interaction has inherent limitation, as it is often limited to specific cells and competitive displacement occurs in vivo. In response to this, we have developed a simple, bio-orthogonal, supramolecular cell-conjugation strategy to construct a cell-based drug delivery system, which is achieved by inserting host (or guest) molecules onto the cell surfaces and nanomedicine surface, respectively. In our studies, a mouse foot swelling inflammation model proved that the supramolecular macrophage-nanomedicine conjugate was efficiently enriched in the foot swelling site, delivered by hand in hand, which was driven by the inflammatory tropism of macrophage. In addition, in an acute pneumonia model in mice, peritoneal macrophage-quercetin-loaded liposomes (mediated via supramolecular hand-holding) significantly improved the pneumonia targeting efficiency of drug-loaded liposomes, and the quercetin-based medicine exhibited signifeicant anti-inflammatory and antioxidant effects and reduced the lung inflammation. This gentle, simple, host-guest interaction-mediated supramolecular cell-hitchhiking drug delivery system provides a new general strategy for the construction of cell-hitchihiking drug delivery systems to meet the needs of various biomedical applications.
Brief introduction
Wang Ruibing, Associate Professor, Institute of Chinese Medical Sciences, University of Macau, Programme Director of the State Key Laboratory of Quality Research in Chinese Medicine, Director of Global Affairs Office, University of Macau. He obtained his BSc and PhD degrees in chemistry, from Jilin University and Queen's University, Canada, respectively. After graduation, he worked in the National Research Council of Canada and the biotech industry for a number of years before joining the University of Macau in 2014. Dr. Wang's current main research interest is the design and application of drug delivery systems based on supramolecular systems. After joining UM, he has published over 100 research papers in Nature Commun., Mater. Today, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Matter, Adv. Funct. Mater., Adv. Sci., ACS Cent. Sci. etc. He has also won several prestigious awards including 2018 Macao Science and Technology Award-Natural Science category, 2019 Chinese Periodic Table of Young Chemist, and 2020 Macau Science and Technology Award- Technological Invention.
02
Syntheses of Pillararene-based Supramolecular Functional Materials and Their Applications in Various Fields
Abstract
Supramolecular chemistry is a dynamic emerging discipline and development in which disciplines such as chemistry, materials, life sciences, and medicine interpenetrate and converge. Crown ethers, cyclodextrins, calixarene, etc., as representatives of the three generations of supramolecular host molecules, have promoted the rapid development of supramolecular chemistry. Pillararenes have become a new star in the macrocyclic host molecules in recent years due to their superior performance in molecular recognition, self-assembly and materials.
At present, the studies on the syntheses and performance of pillararene-based functional materials mainly focus on the following aspects: (1) pillararene-based optical functional materials: including optical switch materials, fluorescent materials, luminescent materials, etc.; (2) pillararene-based functional materials with external stimulus response: including drug release materials, gel materials, detection materials, etc.; (3) pillararene-based adsorption and separation materials: including adsorption and separation materials for gas and solution; (4) pillararene-based supramolecular polymer materials. This article summarizes and prospects the synthesis of pillararene-based supramolecular functional materials and their applications in many fields.
Brief introduction
Dr. Cao Derong, Professor, Ph.D. Supervisor, Director of the Department of Chemistry, South China University of Technology, Professor of the State Key Laboratory of Luminescent Materials and Devices, Adjunct Chief Scientist of the National Institute of Ophthalmology, Singapore, Member of the New Energy Expert Committee of the Chinese Energy Society, Deputy Chairman of the Pharmaceutical Chiral Professional Committee of the Guangdong Pharmaceutical Association, and a member of the Organic Chemistry Professional Committee of the Guangdong Chemical Association. Received a bachelor's and master's degree from Lanzhou University and a joint Ph.D. degree from the University of Mainz in Germany. /Lanzhou University in China, Postdoctoral fellows at the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences and the University of Mainz, Germany; after returning to China in 2000, he worked at the Guangzhou Institute of Chemistry, Chinese Academy of Sciences. Since 2005, he has been engaged in teaching and scientific research at South China University of Technology and engaged in organic chemistry and materials science research, especially in the synthesis of pillararenes and functional materials research has achieved fruitful results. Undertook the National Natural Science Foundation of China, the National Key Research and Development Program sub-projects, the Guangdong Provincial Natural Science Foundation key projects and other topics; published more than 200 SCI papers and in total more than 300 papers, some of the research results were published in high impact journals like Chem. Soc. Rev., Angew. Chem. Int. Ed. and other top international academic journals in the field of chemistry and materials. In 2012, he won the Guangdong Jinbo Award and in 2013 he won the Guangdong Provincial Natural Science Award.
Nanomaterials (ISSN 2079-4991; CODEN: NANOKO) is an international peer-reviewed open access journal published monthly online by MDPI.
Text editor：Miaomiao Su
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