hLife封面荣登《科技日报》

2024年7月12日，hLife封面作为中国学术期刊封面代表，入选《科技日报》中国科技期刊发展深度报道。hLife的封面不仅仅是期刊内容的展示，更是呈现健康科学领域最前沿研究和创新思想的重要窗口。优秀的封面文章不仅引领学科发展，还能为学术界和产业界提供新的见解和策略。每一期，hLife精选代表性研究成果，并与中央美术学院的艺术团队合作，深入浅出地通过艺术表达科学，旨在为学术界和广大读者呈现不一样的封面故事。

hLife封面及解读

1卷1期

高福 

The major stages of medical development are presented from far to near. Elements of basic medical research and related clinical applications are involved in the rotating time-space tunnel composed of green plants, reflecting the development and integration of basic research and clinical applications. Each time when we use a research discovery to strengthen medicine, our weapons are leveled up to better protect the dignity of life. There are also human, animal and environmental elements in the time tunnel, reflecting that animal health, human health and environmental health are mutually linked and interdependent, illustrating the concept of One Health. As we know, the animals are the original or intermediate hosts of many human infectious diseases, and environmental change has a major impact on human health. In front of science, we are all children full of curiosity. By applying innovative scientific advances to clinical applications, we could live in harmony and see a healthier and happier future.

1卷2期

饶毅

For more than 100 years, the fruit fly (Drosophila melanogaster) which is the model organism has contributed to the research of genetics, development, and behavior, revealing fundamental principles, molecular mechanisms, and neural circuits that shed light on human health and diseases. The clock surrounding the fruit fly indicates circadian and sleep behavior. There are a lot of dishes in front of the fly, sybolizing the feeding behavior of a fly. Like us, flies also eat and sleep around the clock, which is regulated by circadian and other environmental inputs. Additionally, the molecule in the picture is guanosine tetraphosphate (ppGpp), the “magic spot” nucleotides originally known as involved in the stringent response in bacteria when there is an amino acid shortage. In the cover study in this issue, ppGpp was found to be the key molecule regulating sleep duration, sleep latency, and starvation-induced sleep loss, building a bridge between feeding and sleep.

2卷1期

Crystal structures of RNA-dependent RNA polymerases from Jingmen tick virus and Alongshan virus

Assessing risk of Bombali virus spillover to humans by mutagenesis analysis of viral glycoprotein

Efficient inhibition of SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants by fusion inhibitor HY3000 peptide

施一

The scientists want to find the Achilles’ heel of the emerging viruses, and then develop countermeasures against the key targets. In this issue, Shi and his colleagues have solved the crystal structures of RNA-dependent RNA polymerase (RdRp) from segmented Jingmeng viruses and identified the key region of the virus genome responsible for the binding and activity of RdRp. They revealed the common and specific structural features that will provide an important basis for drug development against segmented flaviviruses. Moreover, Zhong and his colleagues have assessed the risk of Bombali virus spillover to humans and found that although wild-type BOMV does not efficiently infect human cells, the emergence of mutations in viral GP may boost its ability to spill over to humans. Wang, Gao, and their colleagues have shown that the fusion peptide inhibitor HY3000 is still working against emerging SARS-CoV-2 EG.5, EG.5.1, and BA.2.86 variants.

2卷2期

Insights into varicella-zoster virus assembly from the B- and C-capsid at near-atomic resolution structures

王祥喜

DNA viruses, represented here by a herpesvirus, are characterized by nucleocapsids of remarkably intricate composition and structure. These assemblies, comprised of hundreds of components, exhibit meticulous organization, believed by many to be a testament to the divine design of a creator. This precise organization ensures the stability and orderly delivery of viral genetic material. Delving into these structures promises profound insights into the packaging mechanisms and stability of viral genomes, laying a foundational framework for the development of advanced antiviral therapies. In this issue, Wang and his colleagues present refined Cryo-EM structures of VZV B- and C-capsids, illuminating their assembly and stability. These revelations offer tantalizing glimpses into capsid-NPC interactions, the head-full sensor's nature, and DNA packaging processes. Additionally, the elucidation of the portal structure, replete with potential drug targets, holds promise for the design of novel antiviral agents.

2卷3期

张子杰

A girl stands firm upon a majestic dragon boat, the embodiment of ancient Chinese culture and resilience, with an outsized syringe, a symbol of novel vaccines technologies. The girl battles a tempest of COVID-19 virus that has loomed over the world, using biotechnology. Scientists relentlessly navigate the stormy seas of infectious diseases, which signifies not only the ongoing efforts to combat the current pandemic but also the broader commitment to safeguarding public health through science and innovation. Yu and his colleagues presented a randomized clinical trial of omicron XBB.1.5-containing bivalent COVID-19 mRNA vaccine in head-to-head comparison with other two mRNA vaccines encoding earlier variants, clarifying that newer variant-matched vaccine elicits an enhanced immune response against newly emerged variants. As we navigate through intricate molecular landscapes, vaccines herald a new frontier in our enduring battle against existing and newly emerged pathogens, promising a future where health prevails.

2卷4期

王显花

杨茂君

The mitochondrion undergoes mitoflashes, shown as flaming peaks for heat production. As the powerhouse of the cell, mitochondria produce ATP, the energy currency of life, through respiratory chain complexes that can form a megacomplex (shown in the bubble), whose structure is being resolved by Zhang and his colleagues. According to the conformational change of megacomplex, it is concluded that respiratory chain complex I, complex III, and complex IV work in a synergistical manner, in which the activation state of complex I can influence the Rieske domain movement of complex III and the swing range of complex IV. Mitochondria also generate elementary electrochemical excitations in the form of mitoflashes, which represent transient uncoupling of mitochondrial respiration. Chen and her colleagues show a close link between mitoflashes and heat production. They find that when the body is challenged with environmental cold, mitoflashes are extensively activated in brown adipocytes, a specialised cell type for adaptive thermogenesis. As stimulation of brown adipocyte thermogenesis increases systematic energy expenditure, understanding mitoflash signalling in heat production will open up avenues to combat obesity and its associated metabolic disorders.

2卷5期

陆剑

乐敏

The entire image is composed of viral particles, symbolizing the continuous adaptation and evolution of the SARS-CoV-2 population, with scenes of human activity embedded. On the right, a researcher performs in silico simulations to recreate the ongoing evolution of viral populations. Colorful waveforms above signify epidemiological and evolutionary trends captured by the SIRSVIDE model, introduced by Jin et al. This innovative model simulates the transmission and evolutionary dynamics of viral populations, revealing under large susceptible host populations and high mutation rates, viral populations evolve towards higher transmissibility, enhanced immune evasion capabilities, and reduced pathogenicity. On the left, a worker disinfects a public area, representing another study by Huang et al. on the impact of COVID-19-related nonpharmaceutical interventions on diarrheal diseases and zoonotic Salmonella. This cover encapsulates understanding viral evolution requires a holistic perspective considering both the inherent properties of viruses and the myriad ways in which human factors shape the invisible battlefield of infectious diseases.

2卷6期

彭敏

The intricate relationship between our bodies and the trillions of microbes living in our guts is essential to our health. However, this partnership isn't without its challenges, as the metabolic processes of bacteria and our own cells can sometimes clash. A new study has uncovered a crucial mechanism that resolves one such conflict, ensuring male fertility in mice. Qing Shang et al. found that certain enzymes in the body are essential for detoxifying acetate, a byproduct of gut bacteria, to prevent it from reaching harmful levels. When these enzymes, ACSS1 and ACSS2, are absent, acetate builds up in the bloodstream, leading to metabolic acidosis. This condition disrupts spermatogenesis, the process of sperm production, resulting in male infertility. This study highlights an overlooked metabolic incompatibility between hosts and microbiota, which deepens our understanding of host-microbiota interactions and opens up new avenues for addressing fertility issues linked to metabolic dysfunctions.

hLife封面合集

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期刊简介

hLife由高福院士、董晨院士和Jules A. Hoffmann教授（2011诺奖获得者）领衔，是中国科学院微生物研究所主办，中国生物工程学会，浙江大学陈廷烨大健康学院，西湖大学医学院，上海市免疫治疗创新研究院和广州霍夫曼免疫研究所联合支持，与国际出版商爱思唯尔合作的健康科学领域综合性英文期刊。

hLife聚焦健康科学领域的前沿进展，旨在促进基础研究与临床应用的融合发展。期刊发表与医学相关各研究领域最新成果，学科领域包括（但不限于）病原生物学、流行病学、生理学、免疫学、结构生物学、疾病监测、肿瘤、药物、疫苗和健康政策等。

hLife是一本金色开放获取期刊，月刊出版；2022年成功入选“中国科技期刊卓越行动计划高起点新刊”；2023年11月正式创刊。

2025年前hLife接受的稿件免收文章处理费（APC）。

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