每周分子 | Molecule of the Week

Original ACS 美国化学会 ACS美国化学会 2022-07-01

收录于合集 #每周分子 110个

每周分子: 瑞德西韦

Molecule of the Week: Remdesivir

瑞德西韦是由吉利德科学公司(美国加利福尼亚州，福斯特城)开发的一种抗病毒药物，用于抗击2010年代中期西非埃博拉病毒病。它还显示了针对出血热的马尔堡病毒(MARV)、中东呼吸综合征冠状病毒(MERS-coV)和严重急性呼吸综合征冠状病毒(SARS-coV)的活性。

在当前的COVID-19病毒大流行爆发后的几个月内，研究人员开始评估瑞德西韦对抗病毒SARS-CoV-2的能力。迄今已开始的五项三期临床试验中：两项正在中国进行，一项由美国国立卫生研究院(NIH)进行，两项由吉利德进行。所有这些试验都针对患有严重和中度症状的患者。

医学界的共识是，这些试验不会给出确切的结果。不过，研究人员对瑞德西韦可以对部分患者有帮助表现出乐观态度。但是，负责监督NIH试验的美国国家过敏和传染病研究所的临床主任H. Clifford Lane表示：“这些研究可能会给我们一些提示，但我确实认为启动一项专注于早期疾病的研究非常重要。”

除临床试验外，由于瑞德西韦在对抗其他病毒方面已被证明是成功的，因此医生们正探索将其作为COVID-19患者的同情药使用。《华盛顿邮报》最近刊登了一篇families who are seeking experimental treatments的文章。

更多关于瑞德西韦临床试验的详细信息，请参阅最新一期的《化学与化工新闻杂志》。

瑞德西韦信息速览

CAS 登记号	1809249-37-3
SciFinder命名	L-Alanine, N-[(S)-hydroxyphenoxy-phosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
分子式	C₂₇H₃₅N₆O₈P
摩尔质量	602.58 g/mol
外观	白色或灰白色结晶性粉末
溶点	N/A
水溶性	略溶

瑞德西韦危害信息

不是有害物质或混合物

【关于每周分子】

自2001年以来，“每周分子”已成为广受欢迎的栏目。多数分子由读者推荐。每个结构都经由科学家审查，并以3-D和平面图像的形式显示，同时附有该分子简介。可以通过美国化学文摘社 (CAS) 提供的SciFinder中的CAS REGISTRY获取“每周分子”的更多信息。CAS REGISTRY中的每条物质信息都展示了物质的CAS登记号、索引名、通用名、商品名、书目信息等其他更多信息。发送邮件至motw@acs.org推荐您感兴趣的分子吧。

Remdesivir is an antivirus drug that was developed by Gilead Sciences (Foster City, CA) to combat the West African Ebola virus disease epidemic in the mid-2010s. It has also shown activity against the hemorrhagic fever Marburg virus (MARV), the Middle East respiratory syndrome-related coronavirus (MERS-coV), and the severe acute respiratory syndrome coronavirus (SARS-coV).

Within months after the outbreak of the current COVID-19 viral pandemic, researchers began to evaluate the ability of remdesivir to overcome the corresponding virus, SARS-CoV-2. Of the five Phase III trials that have begun to date, two are being conducted in China, one by the US National Institutes of Health, and two by Gilead. All of these trials focus on patients who have severe and moderate cases of the disease.

The consensus in the medical community is that the trials won’t give definitive results. Researchers are optimistic, though, that remdesivir will help some patients. But according to H. Clifford Lane, the clinical director at the National Institutes of Allergy and Infectious Diseases who is overseeing the NIH trial, “The studies might give us some hint, but I do think it will be important to get a study launched that focuses on early disease.”

In addition to the clinical trials, and because of remdesivir’s proven success against other viruses, it is being sought as a compassionate alternative for patients with COVID-19. The Washington Post recently featured an article about families who are seeking experimental treatments.

See the latest issue of Chemical & Engineering News for more extensive information on remdesivir clinical trials.

Remdesivir fast facts

CAS Reg. No.	1809249-37-3
SciFinder nomenclature	L-Alanine, N-[(S)-hydroxyphenoxy-phosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
Empirical formula	C₂₇H₃₅N₆O₈P
Molar mass	602.58 g/mol
Appearance	White to off-white crystalline powder
Melting point	N/A
Water solubility	Very slightly soluble

Remdesivir hazard information

Not a hazardous substance or mixture

About Molecule of the Week

MOTW has been a popular feature on ACS website since 2001. Many molecules are suggested by our website visitors. Every structure is reviewed by a scientist and displayed in 3-D and flat images with a brief description. Each week’s molecule also links to a sample record from the CAS REGISTRY, which is searched using SciFinder. Each record displays the registry number, index name and synonyms, bibliographic information, and more. Send us a molecule suggestion at motw@acs.org.

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