【学术视频】第八届国际磁科学会议 | 捷克科学院物理研究所Vitalii Zablotskii教授

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图 | Vitalii Zablotskii
题   目：Biological effects of high-gradient magnetic fields报告人：Vitalii Zablotskii单   位：Institute of Physics of the Czech Academy of Sciences时   间：2019-10-12地   点：中国科学院合肥物质科学研究院

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报告摘要

As the fields of nanomedicine, magnetotherapy and magnetogenetics intensively grow, knowledge of the interactions between magnetic fields and living cells is of increasing importance. The exact mechanisms of the interaction between magnetic fields and cells still elude our complete understanding. However, some of the fundamental mechanisms were recently identified for different types of cells exposed to a high-gradient magnetic field (HGMF). 

In this report we aim at highlighting recent advances made in identifying fundamental mechanisms by which magnetic gradient forces act on cell fate specification and cell differentiation.

Fig. 1 Cells in a non-uniform magnetic field. 

Let us imagine cells that are in a high-gradient magnetic field, which changes in the both magnitude and direction (Fig. 1). Through what mechanisms do the cells sense a non-uniform magnetic field and how such a field changes the cell fate? We show that magnetic forces generated by high-gradient magnetic fields (▽B>10 kT/m) can be comparable to intracellular forces and therefore may be capable of altering the functionality of an individual cell and tissues in unprecedented ways.

We identify the cellular effectors of such fields and propose novel routes in cell biology predicting new biological effects such as magnetically induced differentiation of stem cells, magnetically assisted cell division or prevention of cells from dividing, magnetically induced cytoskeleton remodeling, magnetic control of the membrane potential and cell-to-cell communication as well as magnetic control of intracellular ROS levels.

We also provide a review of the currently available magnetic systems capable of generating magnetic fields with spatial gradients of up to 10 MT/m. On the basis of experimental facts and theoretical modeling we reveal timescales of cellular responses to high-gradient magnetic fields and suggest an explicit dependence of the cell response time on the magnitude of the magnetic field gradient. 

个人简介

Vitalii Zablotskii is a senior researcher at the Institute of Physics Academy of Sciences of the Czech Republic, working in magnetism and biophysics. His main research activities focus on the study of magnetic field effects on living organisms, targeted magnetic drug and cell delivery as well as magnetic nanostructures and magnetic phase transitions.

会议简介

2019年10月11日-14日，第八届国际磁科学会议在合肥成功举办。本次会议由中国科学院强磁场科学中心、中国科学院强磁场与离子束物理生物学重点实验室和西北工业大学生命学院空间生物实验模拟技术国防重点学科实验室主办，安徽大学物理与材料科学学院协办，并得到了中科院国际合作局的支持。强磁场条件下的科学研究涉及物理学、化学、材料科学、地球科学、生命科学与医学等众多学科。国际磁科学会议是国际上关于磁场下的材料和生命科学研究最有影响力的国际会议之一，吸引了全世界众多专家学者参与。

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