每周分子 | Molecule of the Week

Original ACS 美国化学会 ACS美国化学会 2023-03-12

收录于合集 #每周分子 142个

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每周分子：舍曲林

Molecule of the Week: Sertraline

舍曲林是一种知名已久的抗抑郁药，其药品名称为佐洛特(辉瑞公司)，于1991年获得FDA的批准。其作用模式在抗抑郁药物中很常见，是一种选择性5-羟色胺再摄取抑制剂。其在大多数配方中的活性成分是以盐酸盐形式存在。

舍曲林仍然是一种常用抗抑郁药。但它成功的同时，我们付出了环境方面的代价：今年，南非科学家Lawrence Mzukisi Madikizela和Somandla Ncubeb在一份综述中提及了几十种在海洋生物和海鲜中检测到的药物，其中就包括舍曲林。基于危害信息表所示的水生毒性，这一发现引起了对海洋生物极大的担忧。

舍曲林信息速览

CAS 登记号	79617-96-2
CAS SciFinder命名	1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-
分子式	C₁₇H₁₇Cl₂N
摩尔质量	306.23 g/mol
外观	白色晶体或粉末
沸点	244–246 °C
水溶性	3.8 g/L

舍曲林危害信息

GHS分类：急性毒性，口服，分类4
H302-吞食可能有害
GHS分类：短期(急性)水生危害，分类1
H400-对水生生物有害
GHS分类：长期(慢性)水生生物危害，分类1
H410-对水生生物有害，具有长期影响

【关于每周分子】

自2001年以来，“每周分子”已成为广受欢迎的栏目。多数分子由读者推荐。每个结构都经由科学家审查，并以3-D和平面图像的形式显示，同时附有该分子简介。可以通过美国化学文摘社 (CAS) 提供的CAS SciFinderⁿ中的CAS REGISTRY获取“每周分子”的更多信息。CAS REGISTRY中的每条物质信息都展示了物质的CAS登记号、索引名、通用名、商品名、书目信息等其他更多信息。发送邮件至motw@acs.org推荐您感兴趣的分子吧。

Sertraline, best known by the brand name Zoloft (Pfizer, New York City), is a venerable antidepressant that was approved by the US Food and Drug Administration in 1991. Its mode of action, common among antidepressants, is as a selective serotonin reuptake inhibitor. The active ingredient in most of its formulations is its hydrochloride.

Sertraline continues to be a frequently prescribed antidepressant. But its success has come with an environmental cost: This year, a review by South African scientists Lawrence Mzukisi Madikizela* and Somandla Ncubeb cited dozens of drugs, including sertraline, that have been detected in marine organisms and seafood. This finding is a major concern for ocean life because of the aquatic toxicity statements shown in the hazard information table.

Sertralinefast facts

CAS Reg. No.	79617-96-2
SciFinder nomenclature	1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-
Empirical formula	C₁₇H₁₇Cl₂N
Molar mass	306.23 g/mol
Appearance	White crystals or powder
Boiling point	244–246 °C
Watersolubility	3.8 g/L

Sertralinehazard information

Acute toxicity, oral, category 4
H302-May be harmful if swallowed
Short-term (acute) aquatic hazard, category 1
H400-Harmful to aquatic life
Long-term (chronic) aquatic hazard, category 1
H410-Harmful to aquatic life with long-lasting effects

About Molecule of the Week

MOTW has been a popular feature on ACS website since 2001. Many molecules are suggested by our website visitors. Every structure is reviewed by a scientist and displayed in 3-D and flat images with a brief description. Each week’s molecule also links to a sample record from the CAS REGISTRY, which is searched using CAS SciFinderⁿ. Each record displays the registry number, index name and synonyms, bibliographic information, and more. Send us a molecule suggestion at motw@acs.org.

往期回顾：

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